{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:12:24Z","timestamp":1793211144465,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T00:00:00Z","timestamp":1431907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hospital for Special Surgery Surgeon-in-Chief Fund"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Adverse local tissue reactions (ALTR) associated with tribocorrosion following total hip arthroplasty (THA) have become a significant clinical concern in recent years. In particular, implants featuring metal\u2010on\u2010metal bearing surfaces and modular femoral stems have been reported to result in elevated rates of ALTR. These tribocorrosion\u2010related tissue reactions are characterized by marked necrosis and lymphocytic infiltration, which contrasts sharply with the macrophagic and foreign body giant cell inflammation associated with polyethylene wear particle induced peri\u2010implant osteolysis. In this study, we characterize tribocorrosion\u2010associated ALTR at a molecular level. Gene expression profiling of peri\u2010implant tissue around failing implants identifies upregulation of numerous inflammatory mediators in ALTR, including several interferon gamma inducible factors, most notably the chemokines MIG\/CXCL9 and IP\u201010\/CXCL10. This expression profile is distinct from that associated with polyethylene wear induced osteolysis, which is characterized by induction of markers of alternative macrophage activation, such as chitotriosidase (CHIT\u20101). Importantly, MIG\/CXCL9 and IP\u201010\/CXCL10 are also elevated at the protein level in the synovial fluid and, albeit more moderately, the serum, of ALTR patients, raising the possibility that these factors may serve as circulating biomarkers for the early detection of ALTR in at\u2010risk patients. \u00a9 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1487\u20131497, 2015.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jor.22916","type":"journal-article","created":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T22:39:08Z","timestamp":1430779148000},"page":"1487-1497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Adverse local tissue reaction (ALTR) associated with corrosion products in metal\u2010on\u2010metal and dual modular neck total hip replacements is associated with upregulation of interferon gamma\u2010mediated chemokine signaling"],"prefix":"10.1002","volume":"33","author":[{"given":"Kritti","family":"Kolatat","sequence":"first","affiliation":[{"name":"Hospital for Special Surgery New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Perino","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Wilner","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elianna","family":"Kaplowitz","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin F.","family":"Ricciardi","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Boettner","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey H.","family":"Westrich","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth A.","family":"Jerabek","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Goldring","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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