{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:42:42Z","timestamp":1780479762785,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,7,17]],"date-time":"2015-07-17T00:00:00Z","timestamp":1437091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01 AR051477\u201001"],"award-info":[{"award-number":["R01 AR051477\u201001"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003252","name":"Lund University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003252","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003173","name":"Crafoord Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003173","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Severe knee trauma, such as an ACL disruption, produces aggrecan degradation as evidenced by elevated synovial fluid (SF) N\u2010terminal (393) Alanine\u2013Arginine\u2013Glycine\u2013Serine (ARGS) neoepitope (or ARGS\u2010aggrecan) and is associated with inflammatory activity soon after injury. However, it is not known if this process persists for a substantial time interval following the initial trauma. The purpose of this study was to evaluate relationships between SF ARGS concentrations and an array of cytokines, matrix metalloproteases (MMPs), and tissue inhibitor of metalloproteases (TIMPs) during the initial 6 months following ACL rupture. SF samples from 67 ACL\u2010injured subjects (29 women) were analyzed within 6 months of injury (18\u2013155 days), immediately prior to surgical ACL reconstruction. Relationships between ARGS and individual analyte concentrations, as well as MMP\/TIMP ratios were evaluated. Statistically significant relationships were found between ARGS and basic fibroblast growth factor (FGF2) (<jats:italic>p<\/jats:italic>\u2009=\u20090.03) and TIMP\u20103 (<jats:italic>p<\/jats:italic>\u2009=\u20090.01). Our findings suggest that FGF2, considered to be primarily catabolic in articular cartilage, is not downregulated as ARGS concentration declines over time since injury. In addition, these results support the hypothesis that an upregulation of TIMP\u20103, the primary aggrecanase inhibitor, is elicited in response to increased aggrecan degradation, which may inhibit further cleavage. \u00a9 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1796\u20131803, 2015.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jor.22961","type":"journal-article","created":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T23:41:51Z","timestamp":1435621311000},"page":"1796-1803","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Relationship between synovial fluid ARGS\u2010aggrecan fragments, cytokines, MMPs, and TIMPs following acute ACL injury: A cross\u2010sectional study"],"prefix":"10.1002","volume":"33","author":[{"given":"Timothy W.","family":"Tourville","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation University of Vermont College of Medicine Burlington Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew E.","family":"Poynter","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Vermont College of Medicine Burlington Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"DeSarno","sequence":"additional","affiliation":[{"name":"Deptartment of Medical Biostatistics University of Vermont College of Medicine Burlington Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Struglics","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Lund University Clinical Sciences Lund Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D.","family":"Beynnon","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation University of Vermont College of Medicine Burlington Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21359"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.bot.0000246468.80635.ef"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509350914"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546507307396"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2008.11.004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546511428580"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.07.015"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546508316770"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509338827"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546510373876"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-008-0498-x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546513477838"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546513476481"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3216"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.07.021"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1699-4"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328349c2b1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e318214e886"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.09.005"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-005-0023-5"},{"key":"e_1_2_7_22_1","first-page":"517","article-title":"Post\u2010traumatic osteoarthritis: the role of stress induced chondrocyte damage","volume":"43","author":"Martin JA","year":"2006","journal-title":"Biorheology"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22208"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.02.002"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.08.019"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3845"},{"key":"e_1_2_7_27_1","first-page":"28","article-title":"Markers of altered metabolism in osteoarthritis","volume":"70","author":"Lohmander LS","year":"2004","journal-title":"J Rheumatol Suppl"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546511411654"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(03)00056-5"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2735"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3217"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.07.018"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199904)42:3<534::AID-ANR19>3.0.CO;2-J"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360906"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115742"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.09.017"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.05.006"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.02.001"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200300002-00008"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465000280040201"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3447"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3441"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.122033199"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar630"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23495"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3064"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-014-0065-5"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-014-0441-0"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-010-0002-5"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.11.003"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.J.00929"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.22961","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.22961","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.22961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T04:53:55Z","timestamp":1696395235000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.22961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,17]]},"references-count":50,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1002\/jor.22961"],"URL":"https:\/\/doi.org\/10.1002\/jor.22961","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,17]]},"assertion":[{"value":"2014-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}