{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:41:22Z","timestamp":1791304882156,"version":"4.3.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T00:00:00Z","timestamp":1438128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute of Health","award":["2R01AR055650"],"award-info":[{"award-number":["2R01AR055650"]}]},{"name":"National Institute of Health","award":["1R01AR063717"],"award-info":[{"award-number":["1R01AR063717"]}]},{"name":"Stanford Department of Orthopaedic Surgery"},{"name":"Stanford Child Health Research Institute"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Total joint replacement (TJR) has been widely used as a standard treatment for late\u2010stage arthritis. One challenge for long\u2010term efficacy of TJR is the generation of ultra\u2010high molecular weight polyethylene wear particles from the implant surface that activates an inflammatory cascade which may lead to bone loss, prosthetic loosening and eventual failure of the procedure. Here, we investigate the efficacy of local administration of mutant CCL2 proteins, such as 7ND, on reducing wear particle\u2010induced inflammation and osteolysis in vivo using a mouse calvarial model. Mice were treated with local injection of 7ND or phosphate buffered saline (PBS) every other day for up to 14 days. Wear particle\u2010induced osteolysis and the effects of 7ND treatment were evaluated using micro\u2010CT, histology, and immunofluorescence staining. Compared with the PBS control, 7ND treatment significantly decreased wear particle\u2010induced osteolysis, which led to a higher bone volume fraction and bone mineral density. Furthermore, immunofluorescence staining showed 7ND treatment decreased the number of recruited inflammatory cells and osteoclasts. Together, our results support the feasibility of local delivery of 7ND for mitigating wear particle\u2010induced inflammation and osteolysis, which may offer a promising strategy for extending the life time of TJRs. \u00a9 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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Identification of a mutated protein that inhibits MCP\u20101\u2010mediated monocyte chemotaxis","volume":"269","author":"Zhang YJ","year":"1994","journal-title":"J Biol Chem"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.09.028"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.10.030"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34486"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199906000-00018"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11420-006-9003-6"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200800001-00004"},{"key":"e_1_2_7_24_1","first-page":"3747","article-title":"Suppression of wear\u2010particle\u2010induced pro\u2010inflammatory cytokine and chemokine production in macrophages via NF\u2010jB decoy oligodeoxynucleotide","volume":"10","author":"Lin TH","year":"2014","journal-title":"a preliminary report"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200800001-00015"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3073"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.22977","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.22977","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.22977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T07:54:45Z","timestamp":1696406085000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.22977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,29]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1002\/jor.22977"],"URL":"https:\/\/doi.org\/10.1002\/jor.22977","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,29]]},"assertion":[{"value":"2015-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}