{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T20:35:46Z","timestamp":1773693346710,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC100\u20102314\u2010B\u2010075\u2010079"],"award-info":[{"award-number":["NSC100\u20102314\u2010B\u2010075\u2010079"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC103\u20102321\u2010B\u2010010\u2010024"],"award-info":[{"award-number":["NSC103\u20102321\u2010B\u2010010\u2010024"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Pigmented villonodular synovitis (PVNS) is a benign tissue proliferation characterized by its hyper\u2010vascularity within the lesion. The true etiology and cell source of this disease entity still remain unclear. Mesenchymal stem cells (MSCs) exist in various tissues of human body. However, it has not been clarified whether MSCs could be isolated from tissue of PVNS. Here, we isolated MSCs from PVNS (PVNS\u2010SCs), and by comparing to the MSCs from normal synovium (Syn\u2010SCs) of the same individual, we investigated whether PVNS\u2010SCs differed in the capacity for multi\u2010differentiation and inducing angiogenesis. We first demonstrated that PVNS\u2010SCs existed in the lesion of PVNS of three individuals. Moreover, we showed PVNS\u2010SCs had better osteogenic differentiation potential than Syn\u2010SCs, whereas Syn\u2010SCs had better capacity for adipogenic and chondrogenic differentiation. By genome\u2013wide analysis of gene expression profile using a complementary DNA microarray and comparing to Syn\u2010SCs, we identified in PVNS\u2010SCs a distinct gene expression profile characterized by up\u2010regulation of genes involved in angiogenesis. In vitro and in vivo studies further confirmed that PVNS\u2010SCs had better capacities for promoting angiogenesis. In summary, the identification of PVNS\u2010SCs in PVNS tissue and their distinct angiogenic potential may help elucidate the underlying etiology of this disease. \u00a9 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:395\u2013403, 2016.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jor.23031","type":"journal-article","created":{"date-parts":[[2015,8,20]],"date-time":"2015-08-20T23:04:55Z","timestamp":1440111895000},"page":"395-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multi\u2010lineage differentiation and angiogenesis potentials of pigmented villonodular synovitis derived mesenchymal stem cells \u2010 pathological implication"],"prefix":"10.1002","volume":"34","author":[{"given":"En\u2010Rung","family":"Chiang","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Surgery School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Orthopaedics &amp; Traumatology Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiao\u2010Li","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Orthopaedics &amp; Traumatology Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung\u2010Pan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Surgery School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Orthopaedics &amp; Traumatology Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien\u2010Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Orthopaedics &amp; Traumatology Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tain\u2010Hsiung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Orthopaedics &amp; Traumatology Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih\u2010Chieh","family":"Hung","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Orthopaedics &amp; Traumatology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Pharmacology School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Medical Research Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Institute of Biomedical Sciences Academia Sinica Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198005000-00004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.143.4.877"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.10.1113"},{"key":"e_1_2_7_5_1","first-page":"448","article-title":"Recurrent and non\u2010recurrent pigmented villonodular synovitis 1","volume":"22","author":"Adem C","year":"2002","journal-title":"Ann Pathol"},{"key":"e_1_2_7_6_1","first-page":"327","article-title":"Iron deposits, cell populations and proliferative activity in pigmented villonodular synovitis of the knee joint","volume":"82","author":"Aigner T","year":"1998","journal-title":"Verh Dtsch Ges Pathol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090504"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21212"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X11308020005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801503"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20786"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546512473269"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3182053f58"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.04.011"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.21-3-337"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X656090"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","unstructured":"WangJP Hui YJ Wang ST et al.2011. Recapitulation of fibromatosis nodule by multipotential stem cells in immunodeficient mice. PLoS ONE 6: e24050.","DOI":"10.1371\/journal.pone.0024050"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.02.048"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/4447"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000239142.48188.f6"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.452"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.05394"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-4-54"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22753"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3098"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21641"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20501"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507321103"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.5.2637"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003405"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26409"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.204"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.4.1028"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.23031","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.23031","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.23031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:35:25Z","timestamp":1696358125000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.23031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,18]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1002\/jor.23031"],"URL":"https:\/\/doi.org\/10.1002\/jor.23031","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,18]]},"assertion":[{"value":"2015-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}