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The objective of this study was to determine the influence of age on polyethylene (PE) particle\u2010induced osteolysis in a murine calvarial model comparing 2\u2010month\u2010old (young) versus 24\u2010month\u2010old (old) mice. After PE particle implantation, calvaria were assessed at days (D) 3, D7, D14, and D21 via chemoluminescent imaging for inflammation (L\u2010012 probe). In addition micro\u2010computed tomography (micro\u2010CT) and histomorphometry end points addressed the bone reaction. Inflammation peaked at D7 in young mice and D14 in old mice. Using micro\u2010CT, a nadir of mature bone was recorded at D7 for young mice, versus D21 for old mice. Besides, regenerating bone peaked at distinct timepoints: D7 for young mice versus D21 for old mice. In the young mice group, the histomorphometric findings correlated with micro\u2010CT regenerating bone findings at D7, associated with ample osteo\u00efd deposition. No osteo\u00efd could be histologically quantified in the old mice group at D7. This study demonstrated that the biological reaction to polyethylene particles is highly influenced by age. \u00a9 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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