{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:27:35Z","timestamp":1787509655838,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,10,2]],"date-time":"2015-10-02T00:00:00Z","timestamp":1443744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Platelet rich plasma (PRP) is used to treat many musculoskeletal disorders. We used a canine model to determine the effects of multiple intra\u2010articular injections of leukoreduced PRP (ACP) on anterior cruciate ligament healing, meniscal healing, and progression of osteoarthritis (OA). With Animal Care and Use Committee (ACUC) approval, 12 dogs underwent partial ACL transection and meniscal release in one knee. At weeks 1, 2, 3, 6, and 8 after insult, dogs were treated with intra\u2010articular injections (2\u2009ml) of either ACP (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096) or saline (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096). Dogs were assessed over 6 months to determine comfortable range of motion (CROM), lameness, pain, effusion, kinetics, and radiographic and arthroscopic assessments. At 6\u2010month endpoint, dogs were assessed for ACL material properties and histopathology. Saline\u2010treated dogs had significantly (\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u20090.04) more CROM loss, significantly (\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u20090.01) more pain, significantly (\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u20090.05) more severe lameness, significantly (\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u20090.05) lower function, and significantly (\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u20090.05) lower %Total Pressure Index in affected hindlimbs compared to ACP\u2010treated dogs. Radiographic OA increased significantly (\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u20090.01) over time within each group. Arthroscopically, saline\u2010treated knees showed moderate to severe synovitis, further ACL disruption, and medial compartment cartilage loss, and ACP\u2010treated knees showed evidence of ACL repair and less severe synovitis. ACL material properties in ACP\u2010treated knees were closer to normal than in saline\u2010treated knees, however, the differences were not statistically significant. ACL histopathology was significantly (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u20090.05) less severe in ACP\u2010treated knees compared to saline\u2010treated knees. Five intra\u2010articular injections of leukoreduced PRP had beneficial effects for ACL healing, improved range of motion, decreased pain, and improved limb function for up to 6 months in this model. \u00a9 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:607\u2013615, 2016.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jor.23054","type":"journal-article","created":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T04:46:17Z","timestamp":1443156377000},"page":"607-615","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Multiple injections of leukoreduced platelet rich plasma reduce pain and functional impairment in a canine model of ACL and meniscal deficiency"],"prefix":"10.1002","volume":"34","author":[{"given":"James L.","family":"Cook","sequence":"first","affiliation":[{"name":"Comparative Orthopaedic Laboratory University of Missouri Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Columbia Orthopaedic Group Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantelle C.","family":"Bozynski","sequence":"additional","affiliation":[{"name":"Comparative Orthopaedic Laboratory University of Missouri Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Kuroki","sequence":"additional","affiliation":[{"name":"Comparative Orthopaedic Laboratory University of Missouri Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristi R.","family":"Cook","sequence":"additional","affiliation":[{"name":"Comparative Orthopaedic Laboratory University of Missouri Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Stoker","sequence":"additional","affiliation":[{"name":"Comparative Orthopaedic Laboratory University of Missouri Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferris M.","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Comparative Orthopaedic Laboratory University of Missouri Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,2]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Biologics in orthopaedic surgery","author":"Stannard JP","year":"2015"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-201312000-00004"},{"key":"e_1_2_8_4_1","article-title":"Effect of leukocyte concentration on the efficacy of platelet\u2010rich plasma in the treatment of knee osteoarthritis","author":"Riboh JC","year":"2015","journal-title":"Am J Sports Med"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2015.02.003"},{"key":"e_1_2_8_6_1","article-title":"Does intra\u2010articular platelet\u2010rich plasma injection provide clinically superior outcomes compared with other therapies in the treatment of knee osteoarthritis? 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