{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:56:42Z","timestamp":1790420202747,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T00:00:00Z","timestamp":1450051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010217","name":"Naval Air Warfare Center Aircraft Division","doi-asserted-by":"crossref","award":["N00421-10-C-0049"],"award-info":[{"award-number":["N00421-10-C-0049"]}],"id":[{"id":"10.13039\/100010217","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Department of Veterans Affairs Medical Research"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Lumbar endplate fractures were investigated in different experimental scenarios, however the biomechanical effect of segmental alignment was not outlined. The objectives of this study were to quantify effects of spinal orientation on lumbar spine injuries during single\u2010cycle compressive loads and understand lumbar spine endplate injury tolerance. Twenty lumbar motion segments were compressed to failure. Two methods were used in the preparation of the lumbar motion segments. Group 1 (<jats:italic>n<\/jats:italic>\u2009=\u20097) preparation maintained pre\u2010test sagittal lordosis, whereas Group 2 (<jats:italic>n<\/jats:italic>\u2009=\u200913) specimens had a free\u2010rotational end condition for the cranial vertebra, allowing sagittal rotation of the cranial vertebra to create parallel endplates. Five Group 1 specimens experienced posterior vertebral body fracture prior to endplate fracture, whereas two sustained endplate fracture only. Group 2 specimens sustained isolated endplate fractures. Group 2 fractures occurred at approximately 41% of the axial force required for Group 1 fracture (<jats:italic>p\u2009<\/jats:italic>&lt;\u20090.05). Imaging and specimen dissection indicate endplate injury consistently took place within the confines of the endplate boundaries, away from the vertebral periphery. These findings indicate that spinal alignment during compressive loading influences the resulting injury pattern. This investigation identified the specific mechanical conditions under which an endplate breach will take place. Development of endplate injuries has significant clinical implication as previous research identified internal disc disruption (IDD) and degenerative disc disease (DDD) as long\u2010term consequences of the axial load\u2010shift that occurs following a breach of the endplate. \u00a9 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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