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The standard delivery system for BMP\u20102 is a porous collagen sponge, but we have previously found that the biocompatible, high viscosity carrier, Sucrose acetate isobutyrate (SAIB) is an effective and potentially less invasive alternative. The efficacy of SAIB as a BMP\u20102 delivery system was examined in an open fracture model featuring a femoral osteotomy with periosteal stripping in 9\u2010week\u2010old male Sprague Dawley rats. SAIB containing BMP\u20102 (SAIB\/BMP\u20102) was delivered into the fracture site during surgery and an additional group was further co\u2010treated with zoledronic acid and hydroxyapatite nanoparticles (SAIB\/BMP\u20102\/HA\/ZA). These were compared to untreated fractures and SAIB carrier alone (negative controls), and BMP\u20102 loaded collagen sponge (positive control). The rate of radiographic union and the biomechanical properties of the healed fractures were compared after 6\u2013week. Untreated and SAIB\u2010treated fractures showed poor repair, with 53% and 64%, respectively, not bridged at 6\u2009week. In contrast, collagen\/BMP\u20102, SAIB\/BMP\u20102, and SAIB\/BMP\u20102\/HA\/ZA showed significantly increased union (100%, 100%, and 94%, respectively, <jats:italic>p\u2009<\/jats:italic>&lt;\u20090.05). Four\u2010point bend testing revealed that collagen\/BMP\u20102 and SAIB\/BMP\u20102\/HA\/ZA restored the strength of fractured femora to that of intact femora by 6\u2009week, whereas untreated and SAIB remained less than intact controls by 60% and 67%, respectively (<jats:italic>p\u2009<\/jats:italic>&lt;\u20090.05). Overall, the SAIB\/BMP\u20102\/HA\/ZA formulation was comparable to BMP\u20102 infused collagen sponge in terms of promoting open fractures repair, but with the additional potential for less invasive delivery. \u00a9 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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