{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T03:03:06Z","timestamp":1783825386182,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,4,6]],"date-time":"2016-04-06T00:00:00Z","timestamp":1459900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Articular cartilage calcification is considered a pathological albeit incompletely understood process which is known to be associated with osteoarthritis of the knee and hip. The goal of this study was to determine the prevalence of articular cartilage calcification of the shoulder as a non\u2010weight\u2010bearing joint and to analyze the interrelationship of calcification with age and histological severity of shoulder osteoarthritis in the general population. In a cross\u2010sectional study of 180 humeral heads from 90 donors (<jats:italic>n<\/jats:italic>\u2009=\u200949 male, <jats:italic>n<\/jats:italic>\u2009=\u200941 female; mean age 62.7 years [20\u201393]), cartilage calcification of the humeral head was quantified by digital contact radiography (DCR). Histological OA grade (OARSI) was determined and structural equation modeling (SEM) was used to analyze the interrelationship of cartilage calcification, OARSI and age. The prevalence of articular cartilage calcification was 98.9% (95%CI: [93.96%, 99.97%]) and was independent of gender (<jats:italic>p<\/jats:italic>\u2009=\u20090.55). Cartilage calcification of one shoulder correlated significantly with that of the contralateral side (<jats:italic>r<\/jats:italic>\u2009=\u20090.61, 95%CI: [0.46, 0.73], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). SEM demonstrated significant associations between histological OA grade and cartilage calcification (<jats:italic>r<\/jats:italic>\u2009=\u20090.55, <jats:italic>p<\/jats:italic>\u2009=\u20090.039), between histological OA grade and age (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.59, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) but not between age and cartilage calcification (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.24, <jats:italic>p<\/jats:italic>\u2009=\u20090.116). In conclusion, the prevalence of shoulder cartilage calcification in the general population is higher than anticipated. The high prevalence, its concomitant bilateral manifestation and the association between the amount of cartilage calcification and OA severity, but not age, suggest that cartilage calcification is a systemically driven process with early onset in life and may be a causative factor in the pathogenesis of OA. \u00a9 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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