{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:50:29Z","timestamp":1790650229203,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T00:00:00Z","timestamp":1460505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"West Chester University Provost's Initiative Research Grant"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>The purpose of this study was to determine whether an association existed between self\u2010reported symptom and function scores and tissue turnover or inflammatory biomarker changes after a running bout among individuals with and without an acute knee\u2010injury history. A pre\u2010test\/post\u2010test prospective cohort study design (Level II) of 22 participants was conducted. Eleven physically active individuals with a history of anterior cruciate ligament surgery and\/or meniscus surgery within 4 years of study participation were matched to 11 healthy control participants. All participants completed self\u2010reported outcome measures (Knee Osteoarthritis Outcomes Score and Tegner activity level) assessing knee symptoms and functional levels prior to the run. Blood samples were taken both pre\u2010 and post\u201030\u2010minute run at a prescribed pace on a treadmill to determine serum biomarker concentration changes. Tegner activity levels were inversely related to type II collagen\/type II collagen synthesis marker ratio biomarker changes after the run (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.45, <jats:italic>p<\/jats:italic>\u2009=\u20090.01). Quality\u2010of\u2010life scores pre\u2010exercise were inversely related to interleukin\u20101\u03b2 changes after the run (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.50, <jats:italic>p<\/jats:italic>\u2009=\u20090.02). No other correlation coefficients were statistically significant (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.39 to 0.36). Ultimately, individuals with lower activity and quality\u2010of\u2010life scores experienced greater increases in collagen turnover and inflammation after a running bout, respectively. A gradual increase in activity (e.g., frequency, duration, intensity) may be warranted in this group prior to returning to activities that involve running. \u00a9 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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