{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:57:22Z","timestamp":1785297442753,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T00:00:00Z","timestamp":1464566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>United States military personnel frequently suffer knee injuries. The resulting progressive posttraumatic osteoarthritis (PTOA) causes significant disability in these young high\u2010demand patients for which total knee arthroplasty (TKA) is the only effective treatment of their pain and impairment. Yet the use of this option for treatment of PTOA has not been studied. This retrospective review identified 74 knees in 64 U.S. military personnel who underwent TKA at \u226450 years of age during an 8\u2010year period at a tertiary\u2010care, academic, military medical center. Fifty\u2010five knees (74.3%) experienced one or more prior ligamentous, meniscal, or chondral injuries prior to arthroplasty. Only one subject had a history of osteochondral intra\u2010articular fracture. The average at injury was 29.2 years (95%CI of \u00b12.50) with an average age at arthroplasty of 44.3 years (\u00b11.11). The most common injury was anterior cruciate ligament rupture (<jats:italic>n<\/jats:italic>\u2009=\u200919) with a mean time to TKA of 23.1 (\u00b110.54) and 18.8 years (\u00b17.01) when concomitant meniscal pathology was noted. Nineteen patients were noted to have radiographic and symptomatic end\u2010stage osteoarthritis without a specified etiology at 41.4 years (\u00b11.47) and underwent subsequent TKA. This is the first study to evaluate treatment of end\u2010stage PT OA in young people treated with TKA, finding that the incidence of PTOA as an indication for arthroplasty is significantly higher than among civilians. In this otherwise healthy, high\u2010demand patient population, the rate of OA progression following knee injury is accelerated and the long term implications can be career and life altering. \u00a9 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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