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These processes combine to engender the subsequent development of post\u2010traumatic osteoarthritis (PTOA). To prevent this from happening, it is necessary to inhibit these disparate responses to injury; given their heterogeneity, this is challenging. However, dexamethasone has the necessary pleiotropic properties required of a drug for this purpose. Using in vitro models, we have shown that low doses of dexamethasone sustain the synthesis of cartilage proteoglycans while inhibiting their breakdown after injurious compression in the presence or absence of inflammatory cytokines. Under these conditions, dexamethasone is non\u2010toxic and maintains the viability of chondrocytes exposed chronically to such cytokines as interleukin (IL) \u20101, IL\u20106, and tumor necrosis factor\u2010\u03b1. Moreover, the anti\u2010inflammatory properties of dexamethasone have been appreciated for decades. In view of this information, we have initiated a pilot clinical study to determine whether a single, intra\u2010articular injection of dexamethasone into the wrist shows promise in preventing PTOA after intra\u2010articular fracture of the distal radius.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>CLINICAL SIGNIFICANCE:<\/jats:bold>\n                      Suppressing the various etiopathophysiological responses to injury in the joint is an attractive strategy for lowering the clinical burden of PTOA. The intra\u2010articular administration of dexamethasone soon after injury offers a simple and inexpensive means of accomplishing this. \u00a9 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:406\u2013411, 2017.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jor.23295","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T17:11:33Z","timestamp":1463159493000},"page":"406-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Intra\u2010articular dexamethasone to inhibit the development of post\u2010traumatic osteoarthritis"],"prefix":"10.1002","volume":"35","author":[{"given":"Alan J.","family":"Grodzinsky","sequence":"first","affiliation":[{"name":"Departments of Biological, Electrical and Mechanical Engineering Massachusetts Institute of Technology Cambridge Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering Massachusetts Institute of Technology Cambridge 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