{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:31:47Z","timestamp":1773293507523,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,7,24]],"date-time":"2016-07-24T00:00:00Z","timestamp":1469318400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2016,7,24]],"date-time":"2016-07-24T00:00:00Z","timestamp":1469318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"funder":[{"name":"National Institute of Arthritis and Musculoskeletal"},{"name":"Skin Diseases of the National Institutes of Health","award":["AR060782"],"award-info":[{"award-number":["AR060782"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Orthop. Res."],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1002\/jor.23368","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T20:44:48Z","timestamp":1468529088000},"page":"1007-1017","source":"Crossref","is-referenced-by-count":13,"title":["TLR4 (not TLR2) dominate cognate TLR activity associated with CoCrMo implant particles"],"prefix":"10.1002","volume":"35","author":[{"given":"Lauryn","family":"Samelko","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery; Rush University Medical Center; 1735 W Harrison Chicago Illinois"},{"name":"Department of Immunology; Rush University Medical Center; Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Landgraeber","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics; University Hospital Essen; University of Duisburg-Essen; Hufelandstrabe 55 Essen 45122 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyron","family":"McAllister","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery; Rush University Medical Center; 1735 W Harrison Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery; Rush University Medical Center; 1735 W Harrison Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadim J.","family":"Hallab","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery; Rush University Medical Center; 1735 W Harrison Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,24]]},"reference":[{"key":"10.1002\/jor.23368-BIB0001|jor23368-cit-0001","doi-asserted-by":"crossref","first-page":"8046","DOI":"10.1016\/j.actbio.2013.05.005","article-title":"Osteolysis around total knee arthroplasty: a review of pathogenetic mechanisms","volume":"9","author":"Gallo","year":"2013","journal-title":"Acta Biomater"},{"key":"10.1002\/jor.23368-BIB0002|jor23368-cit-0002","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/BLO.0b013e31804b4147","article-title":"The biology of aseptic osteolysis","volume":"460","author":"Holt","year":"2007","journal-title":"Clin Orthop Relat Res"},{"key":"10.1002\/jor.23368-BIB0003|jor23368-cit-0003","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.arth.2007.11.015","article-title":"Primary and revision arthroplasty surgery caseloads in the United States from 1990 to 2004","volume":"24","author":"Kurtz","year":"2009","journal-title":"J Arthroplasty"},{"key":"10.1002\/jor.23368-BIB0004|jor23368-cit-0004","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/jbm.a.10352","article-title":"Effect of subtoxic concentrations of metal ions on NFkappaB activation in THP-1 human monocytes","volume":"64","author":"Lewis","year":"2003","journal-title":"J Biomed Mater Res A"},{"key":"10.1002\/jor.23368-BIB0005|jor23368-cit-0005","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0142-9612(02)00351-4","article-title":"TNF-alpha secretion and macrophage mortality induced by cobalt and chromium ions in vitro-qualitative analysis of apoptosis","volume":"24","author":"Catelas","year":"2003","journal-title":"Biomater"},{"key":"10.1002\/jor.23368-BIB0006|jor23368-cit-0006","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.1097\/00007632-200310151-00006","article-title":"Spinal implant debris-Induced osteolysis","volume":"28","author":"Hallab","year":"2003","journal-title":"Spine"},{"key":"10.1002\/jor.23368-BIB0007|jor23368-cit-0007","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.20.083001.084359","article-title":"Innate immune recognition","volume":"20","author":"Janeway","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"10.1002\/jor.23368-BIB0008|jor23368-cit-0008","doi-asserted-by":"crossref","first-page":"32378","DOI":"10.1074\/jbc.M110.136895","article-title":"Bacterial pathogen-associated molecular patterns stimulate biological activity of orthopaedic wear particles by activating cognate toll-like receptors","volume":"285","author":"Greenfield","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1002\/jor.23368-BIB0009|jor23368-cit-0009","doi-asserted-by":"crossref","first-page":"5535","DOI":"10.1016\/j.biomaterials.2011.04.046","article-title":"Role of the Toll-like receptor pathway in the recognition of orthopedic implant wear-debris particles","volume":"32","author":"Pearl","year":"2011","journal-title":"Biomater"},{"key":"10.1002\/jor.23368-BIB0010|jor23368-cit-0010","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1002\/jbm.a.34972","article-title":"Toll-like receptors-2 and 4 are overexpressed in an experimental model of particle-induced osteolysis","volume":"102","author":"Valladares","year":"2014","journal-title":"J Biomed Mater Res A"},{"key":"10.1002\/jor.23368-BIB0011|jor23368-cit-0011","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/jor.20979","article-title":"Toll-like receptors and aseptic loosening of hip endoprosthesis-a potential to respond against danger signals","volume":"28","author":"Lahdeoja","year":"2010","journal-title":"J Orthop Res"},{"key":"10.1002\/jor.23368-BIB0012|jor23368-cit-0012","doi-asserted-by":"crossref","first-page":"810","DOI":"10.3899\/jrheum.100732","article-title":"Expression of Toll-like receptors and their signaling pathways in rheumatoid synovitis","volume":"38","author":"Tamaki","year":"2011","journal-title":"J Rheumatol"},{"key":"10.1002\/jor.23368-BIB0013|jor23368-cit-0013","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1086\/591536","article-title":"Outcome of enterococcal prosthetic joint infection: is combination systemic therapy superior to monotherapy","volume":"47","author":"El Helou","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1002\/jor.23368-BIB0014|jor23368-cit-0014","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/jor.20826","article-title":"Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: a novel mechanism for implant debris reactivity","volume":"27","author":"Caicedo","year":"2008","journal-title":"J Orthop Res"},{"key":"10.1002\/jor.23368-BIB0015|jor23368-cit-0015","first-page":"182","article-title":"Biologic effects of implant debris","volume":"67","author":"Hallab","year":"2009","journal-title":"Bull NYU Hosp Jt Dis"},{"key":"10.1002\/jor.23368-BIB0016|jor23368-cit-0016","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1615\/JLongTermEffMedImplants.2014010118","article-title":"Implant debris particle size affects serum protein adsorption which may contribute to particle size-based bioreactivity differences","volume":"24","author":"Reddy","year":"2014","journal-title":"J Long Term Eff Med Implants"},{"key":"10.1002\/jor.23368-BIB0017|jor23368-cit-0017","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1002\/jbm.a.32627","article-title":"Soluble ions more than particulate cobalt-alloy implant debris induce monocyte costimulatory molecule expression and release of proinflammatory cytokines critical to metal-induced lymphocyte reactivity","volume":"93","author":"Caicedo","year":"2010","journal-title":"J Biomed Mater Res A"},{"key":"10.1002\/jor.23368-BIB0018|jor23368-cit-0018","doi-asserted-by":"crossref","first-page":"965","DOI":"10.4049\/jimmunol.1500591","article-title":"CD56bright","volume":"195","author":"Morandi","year":"2015","journal-title":"J Immunol"},{"key":"10.1002\/jor.23368-BIB0019|jor23368-cit-0019","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1086\/315093","article-title":"Relationship between plasma levels of lipopolysaccharide (LPS) and LPS-binding protein in patients with severe sepsis and septic shock","volume":"180","author":"Opal","year":"1999","journal-title":"J Infect Dis"},{"key":"10.1002\/jor.23368-BIB0020|jor23368-cit-0020","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.ajo.2008.06.031","article-title":"Nonparametric vs. parametric tests of location in biomedical research","volume":"147","author":"Kitchen","year":"2009","journal-title":"Am J Ophthalmol"},{"key":"10.1002\/jor.23368-BIB0021|jor23368-cit-0021","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1615\/JLongTermEffMedImplants.2014010564","article-title":"Innate immune reactions in septic and aseptic osteolysis around hip implants","volume":"24","author":"Pajarinen","year":"2014","journal-title":"J Long Term Eff Med Implants"},{"key":"10.1002\/jor.23368-BIB0022|jor23368-cit-0022","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/jbm.b.30150","article-title":"Does endotoxin contribute to aseptic loosening of orthopedic implants","volume":"72","author":"Greenfield","year":"2005","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1002\/jor.23368-BIB0023|jor23368-cit-0023","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1126\/science.1240988","article-title":"Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock","volume":"341","author":"Hagar","year":"2013","journal-title":"Science"},{"key":"10.1002\/jor.23368-BIB0024|jor23368-cit-0024","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1002\/jor.21369","article-title":"Toll-like receptors and their adaptors are regulated in macrophages after phagocytosis of lipopolysaccharide-coated titanium particles","volume":"29","author":"Hirayama","year":"2011","journal-title":"J Orthop Res"},{"key":"10.1002\/jor.23368-BIB0025|jor23368-cit-0025","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/jbm.a.35581","article-title":"Lipoteichoic acid modulates inflammatory response in macrophages after phagocytosis of titanium particles through Toll-like receptor 2 cascade and inflammasomes","volume":"104","author":"Naganuma","year":"2016","journal-title":"J Biomed Mater Res A"},{"key":"10.1002\/jor.23368-BIB0026|jor23368-cit-0026","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1002\/jbm.a.32495","article-title":"Titanium particles modulate expression of Toll-like receptor proteins","volume":"92","author":"Pajarinen","year":"2010","journal-title":"J Biomed Mater Res A"},{"key":"10.1002\/jor.23368-BIB0027|jor23368-cit-0027","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1365-2249.2004.02433.x","article-title":"Differential expression of Toll-like receptor (TLR)-2 and TLR-4 on monocytes in human sepsis","volume":"136","author":"Armstrong","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/jor.23368-BIB0028|jor23368-cit-0028","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.chom.2009.12.008","article-title":"Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion","volume":"7","author":"Shimada","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1002\/jor.23368-BIB0029|jor23368-cit-0029","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1002\/jor.23368-BIB0030|jor23368-cit-0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-4636(199910)47:1<1::AID-JBM1>3.0.CO;2-8","article-title":"Interferon-gamma exacerbates polymethylmethacrylate particle-induced interleukin-6 release by human monocyte\/macrophages in vitro","volume":"47","author":"Trindade","year":"1999","journal-title":"J Biomed Mater Res"},{"key":"10.1002\/jor.23368-BIB0031|jor23368-cit-0031","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.4049\/jimmunol.168.9.4701","article-title":"Toll-like receptor (TLR) 2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses","volume":"168","author":"Sabroe","year":"2002","journal-title":"J Immunol"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.23368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.23368","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/jor.23368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T07:03:51Z","timestamp":1718694231000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.23368"}},"subtitle":["PATHOGEN RECEPTOR DEPENDENT IMMUNE REACTIVITY TO IMPLANT PARTICLES"],"short-title":[],"issued":{"date-parts":[[2016,7,24]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"URL":"https:\/\/doi.org\/10.1002\/jor.23368","archive":["Portico"],"relation":{},"ISSN":["0736-0266"],"issn-type":[{"value":"0736-0266","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7,24]]}}}