{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T07:51:11Z","timestamp":1787039471615,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T00:00:00Z","timestamp":1492992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR065995"],"award-info":[{"award-number":["AR065995"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Classic Ehlers\u2013Danlos syndrome (EDS) patients suffer from connective tissue hyperelasticity, joint instability, skin hyperextensibility, tissue fragility, and poor wound healing due to heterozygous mutations in <jats:italic>COL5a1<\/jats:italic> or <jats:italic>COL5a2<\/jats:italic> genes. This study investigated the roles of collagen V in establishing structure and function in uninjured patellar tendons as well as in the injury response using a <jats:italic>Col5a1<jats:sup>+\/\u2212<\/jats:sup><\/jats:italic> mouse, a model for classic EDS. These analyses were done comparing tendons from a classic EDS model (<jats:italic>Col5a1<jats:sup>+\/\u2212<\/jats:sup><\/jats:italic>) with wild\u2010type controls. Tendons were subjected to mechanical testing, histological, and fibril analysis before injury as well as 3 and 6 weeks after injury. We found that <jats:italic>Col5a1<jats:sup>+\/\u2212<\/jats:sup><\/jats:italic> tendons demonstrated diminished recovery of mechanical competency after injury as compared to normal wild\u2010type tendons, which recovered their pre\u2010injury values by 6 weeks post injury. Additionally, the <jats:italic>Col5a1<jats:sup>+\/\u2212<\/jats:sup><\/jats:italic>tendons demonstrated altered fibril morphology and diameter distributions compared to the wild\u2010type tendons. This study indicates that collagen V plays an important role in regulating collagen fibrillogenesis and the associated recovery of mechanical integrity in tendons after injury. In addition, the dysregulation with decreased collagen V expression in EDS is associated with a diminished injury response. The results presented herein have the potential to direct future targeted therapeutics for classic EDS patients. \u00a9 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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