{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:43:33Z","timestamp":1781138613979,"version":"3.54.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T00:00:00Z","timestamp":1497312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Netherlands Institute of Regenerative Medicine (NIRM)","award":["FES0908"],"award-info":[{"award-number":["FES0908"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Screw fixation in osteoporotic patients is becoming an increasing problem in orthopaedic surgery as deterioration of cortical and cancellous bone hamper biomechanical stability and screw fixation. This might result in delayed weight\u2010bearing or failure of instrumentation. We hypothesized that local peri\u2010operative shock wave treatment can optimize osseointegration and subsequent screw fixation. In eight female Wistar rats, two cancellous and two cortical bone screws were implanted in both femora and tibiae. Immediately after implantation, 3.000 unfocused extracorporeal shock waves (energy flux density 0.3\u2009mJ\/mm<jats:sup>2<\/jats:sup>) were applied to one side. The other side served as non\u2010treated internal control. Evaluation of osseointegration was performed after 4 weeks with the use of microCT scanning, histology with fluorochrome labeling, and pull\u2010out tests of the screws. Four weeks after extracorporeal shock wave treatment, treated legs exhibited increased bone formation and screw fixation around cortical screws as compared to the control legs. This was corroborated by an increased pull\u2010out of the shock wave treated cortical screws. The cancellous bone screws appeared not to be sensitive for shock wave treatment. Formation of neocortices after shock wave therapy was observed in three of eight animals. Furthermore, de novo bone formation in the bone marrow was observed in some animals. The current study showed bone formation and improved screw fixation as a result of shock wave therapy. New bone was also formed at locations remote from the screws, hence, not contributing to screw fixation. Further, research is warranted to make shock wave therapy tailor\u2010made for fracture fixation. \u00a9 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:76\u201384, 2018.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jor.23615","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T16:50:58Z","timestamp":1495731058000},"page":"76-84","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Optimization of screw fixation in rat bone with extracorporeal shock waves"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1743-7690","authenticated-orcid":false,"given":"Marianne K. E.","family":"Koolen","sequence":"first","affiliation":[{"name":"Department of Orthopaedics University Medical Center Utrecht UMC Utrecht G.05.228 P.O. Box 85500 Utrecht 3508 GA The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moyo C.","family":"Kruyt","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics University Medical Center Utrecht UMC Utrecht G.05.228 P.O. Box 85500 Utrecht 3508 GA The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir A.","family":"Zadpoor","sequence":"additional","affiliation":[{"name":"Faculty of Mechanical Department of Biomechanical Engineering Maritime, and Materials Engineering Delft University of Technology Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fetullah C.","family":"\u00d6ner","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics University Medical Center Utrecht UMC Utrecht G.05.228 P.O. Box 85500 Utrecht 3508 GA The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrie","family":"Weinans","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics University Medical Center Utrecht UMC Utrecht G.05.228 P.O. Box 85500 Utrecht 3508 GA The Netherlands"},{"name":"Faculty of Mechanical Department of Biomechanical Engineering Maritime, and Materials Engineering Delft University of Technology Delft The Netherlands"},{"name":"Department of Rheumatology and Clinical Immunology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olav P.","family":"van der Jagt","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Elisabeth\u2010TweeSteden Hospital Tilburg The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,13]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"United Nations DOEaSA Population Division. 2015. World Population Prospects: The 2015 Revision Methodology of the United Nations Population Estimates and Projections. ESA\/P\/WP.242."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-013-0136-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62349-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68891-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.03.024"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.50"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0172-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-007-0515-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-199310000-00006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20505"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.04.017"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00590-013-1215-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.88B10.17683"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2014.02.005"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1763-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200910000-00007"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-014-0245-9"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200303000-00005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.J.00155"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2010.12.018"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23193"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orthres.2004.04.001"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.051009"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1777-0"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2003.09.026"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.01535"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20910"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.H.00841"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0b013e3181b26470"},{"key":"e_1_2_7_31_1","first-page":"718","article-title":"[Bone fracture and the healing mechanisms. Application of the extracorporeal shock wave on treatment of fracture]","volume":"19","author":"Ikeda K","year":"2009","journal-title":"Clin Calcium"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0b013e3181cad510"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2015.06.035"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1231-y"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.E.00174"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22258"},{"key":"e_1_2_7_37_1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0301-5629(88)90115-9","article-title":"A model of extracorporeal shock wave action: tandem action of shock waves","volume":"14","author":"Delius M","year":"1988","journal-title":"Ultrasound Med Biol"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200106000-00003"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(98)00070-2"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2011.0573"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2012.08.026"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000128279"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950x.2004.04013.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jor.2013.04.005"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-014-1976-5"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-5629(95)00030-5"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-003-0043-3"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.N.01056"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-005-0958-z"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040143"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.23615","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.23615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T01:46:38Z","timestamp":1695606398000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.23615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,13]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/jor.23615"],"URL":"https:\/\/doi.org\/10.1002\/jor.23615","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,13]]},"assertion":[{"value":"2017-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}