{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T02:44:32Z","timestamp":1781232272887,"version":"3.54.1"},"reference-count":117,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T00:00:00Z","timestamp":1498608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR066562"],"award-info":[{"award-number":["R01AR066562"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>We completed a systematic literature review of in vivo animal models that use arthrotomy\u2010based methods to study particle\u2010induced peri\u2010implant osteolysis. The purpose of the review was to characterize the models developed to date, to determine the questions addressed, to assess scientific rigor and transparency, and to identify gaps in knowledge. We probed three literature databases (Medline, Embase, and Scopus) and found 77 manuscripts that fit the search parameters. In the most recent 10 years, researchers mainly used rat and mouse models, whereas in the previous 20 years, large animal, canine, and rabbit models were more common. The studies have demonstrated several pathophysiology pathways, including macrophage migration, particle phagocytosis, increased local production of cytokines and lysosomal enzymes, elevated bone resorption, and suppressed bone formation. The effect of variation in particle characteristics and concentration received limited attention with somewhat mixed findings. Particle contamination by endotoxin was shown to exacerbate peri\u2010implant osteolysis. The possibility of early diagnosis was demonstrated through imaging and biomarker approaches. Several studies showed that both local and systemic delivery of bisphosphonates inhibits the development of particle\u2010induced osteolysis. Other methods of inhibiting osteolysis include the use of anabolic agents and altering the implant design. Few studies examined non\u2010surgical rescue of loosened implants, with conflicting results with alendronate. We found that the manuscripts often lacked the methodological detail now advocated by the ARRIVE guidelines, suggesting that improvement in reporting would be useful to maximize rigor and transparency. \u00a9 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2595\u20132605, 2017.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jor.23619","type":"journal-article","created":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T13:04:26Z","timestamp":1495803866000},"page":"2595-2605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Arthrotomy\u2010based preclinical models of particle\u2010induced osteolysis: A systematic review"],"prefix":"10.1002","volume":"35","author":[{"given":"Meghan M.","family":"Moran","sequence":"first","affiliation":[{"name":"Department of Cell &amp; Molecular Medicine Rush University Medical Center Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany M.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Cell &amp; Molecular Medicine Rush University Medical Center Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan D.","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Cell &amp; Molecular Medicine Rush University Medical Center Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarjit S.","family":"Virdi","sequence":"additional","affiliation":[{"name":"Department of Cell &amp; Molecular Medicine Rush University Medical Center Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale Rick","family":"Sumner","sequence":"additional","affiliation":[{"name":"Department of Cell &amp; Molecular Medicine Rush University Medical Center Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.H.00155"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197456070-00005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199009000-00013"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198365050-00001"},{"key":"e_1_2_8_6_1","first-page":"182","article-title":"Biologic effects of implant debris","volume":"67","author":"Hallab NJ","year":"2009","journal-title":"Bull NYU Hosp Jt Dis"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000238813.95035.1b"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.128"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820110202"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21554"},{"key":"e_1_2_8_11_1","first-page":"1218","volume-title":"Surgery of the hip","author":"Gooding CR","year":"2013"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2014.12.021"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.01.074"},{"key":"e_1_2_8_14_1","first-page":"145","volume-title":"Surgery of the hip","author":"Sumner DR","year":"2013"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200704000-00012"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30345"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199604)30:4<463::AID-JBM4>3.0.CO;2-N"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.06.035"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2013.0962"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-014-3786-4"},{"key":"e_1_2_8_21_1","first-page":"1334","article-title":"Prolonged inflammatory reactions induced by artificial ceramics in the rat air pouch model","volume":"15","author":"Nagase M","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740410005944"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650080907"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65266-2"},{"key":"e_1_2_8_25_1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1302\/0301-620X.78B4.0780641","article-title":"Periprosthetic bone resorption","volume":"78","author":"Aspenberg P","year":"1996","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198870020-00015"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31665"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100180602"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(02)00150-X"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199807000-00007"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00120340"},{"key":"e_1_2_8_32_1","first-page":"1","article-title":"Wear and osteolysis in total joint replacements","volume":"278","author":"Kadoya Y","year":"1998","journal-title":"Acta Orthop Scand Suppl"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.02.003"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-010-1143-0"},{"key":"e_1_2_8_35_1","first-page":"302","volume-title":"The adult hip: hip arthroplasty surgery","author":"Nich C","year":"2016"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/014107680309600304"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.005"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.11.039"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.72351"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22607"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34029"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164701317269102"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-014-1310-x"},{"key":"e_1_2_8_44_1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/00003086-199012000-00017","article-title":"Tissue changes around loose prostheses. A canine model to investigate the effects of an antiinflammatory agent","volume":"261","author":"Spector M","year":"1990","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199306000-00006"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.83B3.10734"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jab.770060402"},{"key":"e_1_2_8_48_1","first-page":"106","article-title":"Aseptic loosening in uncemented total hip arthroplasty in a canine model","volume":"319","author":"Dowd JE","year":"1995","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2005.02.004"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30115"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orthres.2003.10.012"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-005-0062-3"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199711000-00005"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.84B6.12111"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016470510030850"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.83B3.10667"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.11.058"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-005-0008-4"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164700317362181"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164701317269094"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016470308540836"},{"key":"e_1_2_8_62_1","first-page":"69","article-title":"Biochemical and histological evaluation of the synovial\u2010like tissue around failed (loose) total joint replacement prostheses in human subjects and a canine model","volume":"11","author":"Thornhill TS","year":"1990","journal-title":"Biomaterials"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453670710014581"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.10.020"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200003000-00021"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.20038"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199822)43:2<123::AID-JBM6>3.0.CO;2-Q"},{"key":"e_1_2_8_68_1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/00003086-199211000-00039","article-title":"Prostaglandin E2 production by the membrane surrounding loose and fixated cemented tibial hemiarthroplasties in the rabbit knee","volume":"284","author":"Goodman SB","year":"1992","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.3109\/08941939309141628"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820270215"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.82B4.0820595"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.78B1.0780032"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.83B4.0830588"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200202000-00011"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-010-0229-x"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200104)44:4<956::AID-ANR153>3.0.CO;2-3"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2012.1"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20342"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.07.032"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.03.010"},{"key":"e_1_2_8_81_1","first-page":"21","article-title":"The susceptibility of smooth implant surfaces to periimplant fibrosis and migration of polyethylene wear debris","volume":"311","author":"Bobyn JD","year":"1995","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.10072"},{"key":"e_1_2_8_83_1","first-page":"261","article-title":"Migration of polyethylene particles around stable implants in an animal model","volume":"9","author":"Lalor PA","year":"1999","journal-title":"J Long Term Eff Med Implants"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21062"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008936830622"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016470216314"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00523-4"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.04.024"},{"key":"e_1_2_8_89_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3928\/0147-7447-20020101-17","article-title":"Inhibition of particulate debris\u2010induced osteolysis by alendronate in a rat model","volume":"25","author":"Thadani PJ","year":"2002","journal-title":"Orthopedics"},{"key":"e_1_2_8_90_1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/jbm.a.32531","article-title":"In vivo response to cross\u2010linked polyethylene and polycarbonate\u2010urethane particles","volume":"93","author":"Smith RA","year":"2010","journal-title":"J Biomed Mater Res A"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(01)00155-3"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-004-0846-8"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(19990615)45:4<363::AID-JBM11>3.0.CO;2-3"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100120410"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139793"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37697"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20038"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.G.00409"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.79B5.7631"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30803"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.02.003"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31175"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.05.031"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orthres.2004.10.004"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453670510041321"},{"key":"e_1_2_8_106_1","first-page":"559","article-title":"Histomorphometric analysis of the intramedullary bone response to titanium particles in wild\u2010type and IL\u20101R1 knock\u2010out mice: a preliminary study","volume":"84","author":"Bragg B","year":"2007","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1645-5"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.11.024"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30120"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2010.64"},{"key":"e_1_2_8_111_1","first-page":"252","volume-title":"The adult hip: hip arthroplasty surgery","author":"Wimmer MA","year":"2016"},{"key":"e_1_2_8_112_1","first-page":"617","volume-title":"The adult hip: hip arthroplasty surgery","author":"Ries MD","year":"2016"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-013-0182-z"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1998"},{"key":"e_1_2_8_115_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1302\/0301-620X.75B2.8444949","article-title":"Hydroxyapatite coating converts fibrous tissue to bone around loaded implants","volume":"75","author":"Soballe K","year":"1993","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100980"},{"key":"e_1_2_8_117_1","doi-asserted-by":"crossref","first-page":"e574","DOI":"10.3928\/01477447-20110714-50","article-title":"Teriparatide (rh [1\u201034] PTH) improved osteointegration of a hemiarthroplasty with signs of aseptic loosening","volume":"34","author":"Oteo\u2010Alvaro A","year":"2011","journal-title":"Orthopedics"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4032368"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.23619","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.23619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T10:53:00Z","timestamp":1719226380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.23619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,28]]},"references-count":117,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/jor.23619"],"URL":"https:\/\/doi.org\/10.1002\/jor.23619","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,28]]},"assertion":[{"value":"2016-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}