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In this study, we confirmed that CCR7 protein expression is elevated in synovial tissue from OA patients by immunohistochemical staining. We then investigated whether <jats:italic>Ccr7<\/jats:italic> deficiency impacted structural and functional joint degeneration utilizing a murine model of OA. OA\u2010like disease was induced in male C57BL\/6 and <jats:italic>Ccr7<\/jats:italic>\u2010deficient (<jats:italic>Ccr7<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>) mice by destabilization of the medial meniscus (DMM). Functional deficits were measured by computer integrated monitoring of spontaneous activity every 4 weeks after DMM surgery up 16 weeks. Joint degeneration was evaluated at 6 and 19 weeks post\u2010surgery by histopathology, and subchondral bone changes analyzed by microCT. Results showed reduction in locomotor activities in DMM\u2010operated C57BL\/6 mice by 8 weeks, while activity decreases in <jats:italic>Ccr7<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice were delayed until 16 weeks. Histopathologic evaluation showed minimal protection from early cartilage degeneration (<jats:italic>p\u2009<\/jats:italic>=\u20090.06) and osteophytosis (<jats:italic>p<\/jats:italic>\u2009=\u20090.04) in <jats:italic>Ccr7<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice 6 weeks post\u2010DMM compared to C57BL\/6 controls, but not at 19 weeks. However, subchondral bone mineral density (<jats:italic>p<\/jats:italic>\u2009=\u20090.03) and histologic sclerosis (<jats:italic>p<\/jats:italic>\u2009=\u20090.02) increased in response to surgery in C57BL\/6 mice at 6 weeks, while <jats:italic>Ccr7<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice were protected from these changes. Our results are the first to demonstrate a role for <jats:italic>Ccr7<\/jats:italic> in early development of functional deficits and subchondral bone changes in the DMM model. Understanding the mechanism of <jats:italic>Ccr7<\/jats:italic> receptor signaling in the initiation of joint pathology and disability will inform the development of innovative therapies to slow symptomatic OA development after injury. Published 2017. This article is a U.S. Government work and is in the public domain in the USA. J Orthop Res 36:864\u2013875, 2018.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jor.23671","type":"journal-article","created":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T13:36:37Z","timestamp":1501680997000},"page":"864-875","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Chemokine receptor\u20107 (CCR7) deficiency leads to delayed development of joint damage and functional deficits in a murine model of osteoarthritis"],"prefix":"10.1002","volume":"36","author":[{"given":"Nisha","family":"Sambamurthy","sequence":"first","affiliation":[{"name":"Translational Musculoskeletal Research Center Corporal Michael J. 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