{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:26Z","timestamp":1786978106397,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T00:00:00Z","timestamp":1503273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["N01\u2010AR\u20102\u20102258"],"award-info":[{"award-number":["N01\u2010AR\u20102\u20102258"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["N01\u2010AR\u20102\u20102259"],"award-info":[{"award-number":["N01\u2010AR\u20102\u20102259"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["N01\u2010AR\u20102\u20102260"],"award-info":[{"award-number":["N01\u2010AR\u20102\u20102260"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["N01\u2010AR\u20102\u20102261"],"award-info":[{"award-number":["N01\u2010AR\u20102\u20102261"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["N01\u2010AR\u20102\u20102262"],"award-info":[{"award-number":["N01\u2010AR\u20102\u20102262"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01\u2010AR065977"],"award-info":[{"award-number":["R01\u2010AR065977"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      We assessed which combinations of risk factors can classify adults who develop accelerated knee osteoarthritis (KOA) or not and which factors are most important. We conducted a case\u2010control study using data from baseline and the first four annual visits of the Osteoarthritis Initiative. Participants had no radiographic KOA at baseline (Kellgren\u2010Lawrence [KL]&lt;2). We classified three groups (matched on sex): (i) accelerated KOA:\n                      <jats:styled-content>&gt;<\/jats:styled-content>\n                      1 knee developed advance\u2010stage KOA (KL\u2009=\u20093 or 4) within 48 months; (ii) typical KOA:\n                      <jats:styled-content>&gt;<\/jats:styled-content>\n                      1 knee increased in radiographic scoring (excluding those with accelerated KOA); and (iii) No KOA: no change in KL grade by 48 months. We selected eight predictors: Serum concentrations for C\u2010reactive protein, glycated serum protein (GSP), and glucose; age; sex; body mass index; coronal tibial slope, and femorotibial alignment. We performed a classification and regression tree (CART) analysis to determine rules for classifying individuals as accelerated KOA or not (no KOA and typical KOA). The most important baseline variables for classifying individuals with incident accelerated KOA (in order of importance) were age, glucose concentrations, BMI, and static alignment. Individuals &lt;63.5 years were likely not to develop accelerated KOA, except when overweight. Individuals &gt;63.5 years were more likely to develop accelerated KOA except when their glucose levels were\n                      <jats:styled-content>&gt;<\/jats:styled-content>\n                      81.98\u2009mg\/dl and they did not have varus malalignment. The unexplained variance of the CART\u2009=\u200969%. These analyses highlight the complex interactions among four risk factors that may classify individuals who will develop accelerated KOA but more research is needed to uncover novel risk factors. \u00a9 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:876\u2013880, 2018.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jor.23675","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T08:02:42Z","timestamp":1501833762000},"page":"876-880","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Risk factors can classify individuals who develop accelerated knee osteoarthritis: Data from the osteoarthritis initiative"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6098-4273","authenticated-orcid":false,"given":"Jeffrey B.","family":"Driban","sequence":"first","affiliation":[{"name":"Division of Rheumatology Tufts Medical Center 800 Washington Street, Box 406 Boston 02111 Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy E.","family":"McAlindon","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Tufts Medical Center 800 Washington Street, Box 406 Boston 02111 Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamta","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology Temple University School of Medicine Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori L.","family":"Price","sequence":"additional","affiliation":[{"name":"The Institute for Clinical Research and Health Policy Studies Tufts Medical Center Boston Massachusetts"},{"name":"Tufts Clinical and Translational Science Institute Tufts University Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles B.","family":"Eaton","sequence":"additional","affiliation":[{"name":"Center for Primary Care and Prevention Alpert Medical School of Brown University Pawtucket Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie E.","family":"Davis","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Tufts Medical Center 800 Washington Street, Box 406 Boston 02111 Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Immunology &amp; Allergy, Brigham &amp; Women's Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace H.","family":"Lo","sequence":"additional","affiliation":[{"name":"Medical Care Line and Research Care Line Houston Health Services Research and Development (HSR&amp;D) Center of Excellence Michael E. DeBakey VAMC Houston Texas"},{"name":"Section of Immunology Allergy, and Rheumatology, Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Duryea","sequence":"additional","affiliation":[{"name":"Department of Radiology Brigham &amp; Women's Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary F.","family":"Barbe","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology Temple University School of Medicine Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22359"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X16658032"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-3128-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-3152-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-016-1158-9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23531"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290816"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12778"},{"key":"e_1_2_7_10_1","unstructured":"The Osteoarthritis Initiative.https:\/\/oai.epi\u2010ucsf.org\/."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.86.2.420"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.06.011"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"p 26","DOI":"10.1007\/978-1-4757-3462-1","volume-title":"Regression modeling strategies with applications to linear models, logistic regression, and survival analysis","author":"Harrell FE","year":"2001"},{"key":"e_1_2_7_14_1","first-page":"p. 266","volume-title":"The Elements of Statisical Learning Data Mining, Inference, and Prediction","author":"Hastie T","year":"2001"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204494"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-0976-3"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.06.006"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.07.003"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.04.007"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3564-2"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150016"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.23675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.23675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:54:57Z","timestamp":1695560097000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.23675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,21]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1002\/jor.23675"],"URL":"https:\/\/doi.org\/10.1002\/jor.23675","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,21]]},"assertion":[{"value":"2017-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}