{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:42:38Z","timestamp":1760013758309,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T00:00:00Z","timestamp":1507507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006315","name":"Reumafonds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006315","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>T2\u2010mapping is a widely used quantitative MRI technique in osteoarthritis research. An important challenge for its application in the context of high tibial osteotomy (HTO) is the presence of metallic fixation devices. In this study, we evaluated the possibility of performing T2\u2010mapping after a HTO, by assessing the extent of magnetic susceptibility artifacts and the influence on T2 relaxation times caused by two commonly used fixation devices. T2\u2010mapping with a 3D fast spin\u2010echo sequence at three Tesla was performed on 11 human cadaveric knee joints before and after implantation of a titanium plate and screws (<jats:italic>n<\/jats:italic>\u2009=\u20095) or cobalt chrome staples (<jats:italic>n<\/jats:italic>\u2009=\u20096). Mean T2 relaxation times were calculated in six cartilage regions, located in the distal and posterior cartilage of femoral condyles and the cartilage of tibial plateaus, both medially and laterally. T2 relaxation times before and after the implantation were compared with paired <jats:italic>t<\/jats:italic>\u2010tests and Wilcoxon rank tests. Due to the extent of the magnetic susceptibility artifact, it was not possible to segment the knee cartilage and thus calculate T2 relaxation times in the lateral weight\u2010bearing femoral and tibial cartilage regions only in the cobalt chrome group. In all cartilage regions of the titanium implanted knees and those unaffected by artifacts due to cobalt chrome implants, T2 relaxation times did not significantly differ between the two scans. Our results suggest that accurate T2\u2010mapping after a HTO procedure is possible in all areas after implantation of a titanium fixation device and in most areas after implantation of a cobalt chrome fixation device. \u00a9 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1206\u20131212, 2018.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jor.23729","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T15:41:23Z","timestamp":1505144483000},"page":"1206-1212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Possibility of quantitative T2\u2010mapping MRI of cartilage near metal in high tibial osteotomy: A human cadaver study"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4951-5158","authenticated-orcid":false,"given":"Joost","family":"Verschueren","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands"},{"name":"Department of Radiology &amp; Nuclear Medicine Erasmus MC University Medical Center Rotterdam Gravendijkwal Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duncan E.","family":"Meuffels","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther E.","family":"Bron","sequence":"additional","affiliation":[{"name":"Department of Radiology &amp; Nuclear Medicine Erasmus MC University Medical Center Rotterdam Gravendijkwal Rotterdam The Netherlands"},{"name":"Department of Medical Informatics Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Radiology &amp; Nuclear Medicine Erasmus MC University Medical Center Rotterdam Gravendijkwal Rotterdam The Netherlands"},{"name":"Department of Medical Informatics Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert\u2010Jan","family":"Kleinrensink","sequence":"additional","affiliation":[{"name":"Department of Anatomy Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan A. N.","family":"Verhaar","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sita M. A.","family":"Bierma\u2010Zeinstra","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands"},{"name":"Department of General Practice Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel P.","family":"Krestin","sequence":"additional","affiliation":[{"name":"Department of Radiology &amp; Nuclear Medicine Erasmus MC University Medical Center Rotterdam Gravendijkwal Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr A.","family":"Wielopolski","sequence":"additional","affiliation":[{"name":"Department of Radiology &amp; Nuclear Medicine Erasmus MC University Medical Center Rotterdam Gravendijkwal Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Reijman","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin H. G.","family":"Oei","sequence":"additional","affiliation":[{"name":"Department of Radiology &amp; Nuclear Medicine Erasmus MC University Medical Center Rotterdam Gravendijkwal Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,9]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"2271","article-title":"Prevalence of knee osteoarthritis in the United States: arthritis data from the third national health and nutrition examination survey 1991\u201394","volume":"33","author":"Dillon CF","year":"2006","journal-title":"J Rheumatol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22515"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.212"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1302\/0301-620X.94B11.29601","article-title":"Survivorship of high tibial osteotomy in the treatment of osteoarthritis of the knee: Finnish registry\u2010based study of 3195 knees","volume":"94","author":"Niinimaki TT","year":"2012","journal-title":"J Bone Joint Surg Br"},{"key":"e_1_2_7_6_1","first-page":"CD004019","article-title":"Osteotomy for treating knee osteoarthritis","author":"Brouwer RW","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150663"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22316"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2004.01.071"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-861764"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-013-1777-2"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.07.001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546510392702"},{"key":"e_1_2_7_14_1","first-page":"231","article-title":"3D quantitative imaging of T1rho and T2","author":"Chen W","year":"2011","journal-title":"Proc Annu Meet ISMRM"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2590-3"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2015.02.005"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509349928"},{"key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/s00167-012-2050-2","article-title":"Chevron\u2010type medial malleolar osteotomy: a functional, radiographic and quantitative T2\u2010mapping MRI analysis","volume":"21","author":"Lamb J","year":"2013","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21856"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21967"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.20.3.g00ma10699"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(87)90020-8"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.23729","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.23729","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:22:29Z","timestamp":1695561749000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.23729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,9]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1002\/jor.23729"],"URL":"https:\/\/doi.org\/10.1002\/jor.23729","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"type":"print","value":"0736-0266"},{"type":"electronic","value":"1554-527X"}],"subject":[],"published":{"date-parts":[[2017,10,9]]},"assertion":[{"value":"2017-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}