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Southern Chinese population\u2010based study volunteers were assessed (age range: 18\u201355 years). DSS was defined as the anteroposterior bony spinal canal diameter on T1\u2010weighted axial MRI of L1 to S1. Genotyping was performed using the Illumina HumanOmniZhongHua\u20108 BeadChip. Using the canal diameter as the quantitative trait, genomic statistical analyses was performed. A total of 469 subjects were recruited. The mean axial AP measurements noted were: L1:\u200921.8\u2009mm, L2:\u200921.9\u2009mm, L3:\u200922.4\u2009mm, L4:\u200920.2\u2009mm, L5:\u200919.6\u2009mm, and S1:\u200917.3\u2009mm. Q\u2013Q plots of genome\u2010wide associations found significant differences in L4 and L5 measurements. More significant SNPs were found on chromosomes 8, 11, and 18. Low\u2010density lipoprotein receptor\u2010related protein 5 on chromosome 11 was found to be an important functional gene in canal bony development via candidate gene approach. We found two clusters in the findings with one including the upper levels (L1\u2013L4) and the other the lower levels (L5 and S1). This is the first GWAS addressing DSS. The presence of multiple SNPs suggests a multi\u2010factorial origin of DSS. Further analyses noted region\u2010specific genetic predisposition, delineating distinct upper to lower lumbar regions of DSS. With better understanding of the DSS phenotype and genetic markers, the at\u2010risk population can be identified early, preventative measures can be initiated, lifestyle\/activity modification can be implemented, and more novel and precision\u2010based therapeutics can be developed. \u00a9 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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