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Based on the injection dose and frequency, the rats were randomly divided into five groups (<jats:italic>n<\/jats:italic>\u2009=\u200910 each): subcutaneous injections of saline or 10\u2009\u00b5g\/kg\/w, 20\u2009\u00b5g\/kg\/w, 10\u2009\u00b5g\/kg\/d, and 20\u2009\u00b5g\/kg\/d teriparatide. Four weeks later, the rats were euthanatized, and the fractured tibiae were assessed using X\u2010rays, dual\u2010energy X\u2010ray absorptiometry, micro\u2010computed tomography, the three\u2010point bending biomechanics test, and histology. Compared to the saline control group, either daily or weekly subcutaneous injections of teriparatide significantly increased bone mass, improved the bone microarchitecture, and promoted fracture healing (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). There were no significant differences in bone mineral density (BMD), bone microstructure or bone strength between the 20\u2009\u00b5g\/kg\/w and 10\u2009\u00b5g\/kg\/d groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Teriparatide 20\u2009\u00b5g weekly injections promoted bone fracture healing to the same extent as teriparatide 10\u2009\u00b5g daily injections, which can dramatically decrease the cumulative dosage of teriparatide injections. \u00a9 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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