{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:44:13Z","timestamp":1790858653547,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["1I01RX001198\u201001A2"],"award-info":[{"award-number":["1I01RX001198\u201001A2"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["1I01RX002287\u201001"],"award-info":[{"award-number":["1I01RX002287\u201001"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Flash autoclaving is one of the most frequently utilized methods of sterilizing devices, implants or other materials. For a number of decades, it has been common practice for surgeons to remove implantable devices, flash autoclave and then reimplant them in a patient. Data have not yet indicated the potential for biofilms to survive or remain on the surface of orthopaedic\u2010relevant materials following flash autoclave. In this study, monomicrobial and polymicrobial biofilms were grown on the surface of clinically relevant titanium materials and exposed to flash autoclave settings that included varying times and temperatures. Data indicated that when the sterilization and control temperatures of an autoclave were the same, biofilms were able to survive flash autoclaving that was performed for a short duration. Higher temperature and increased duration rendered biofilms non\u2010viable, but none of the autoclave settings had the ability to remove or disperse the presence of biofilms from the titanium surfaces. These findings may be beneficial for facilities, clinics, or hospitals to consider if biofilms are suspected to be present on materials or devices, in particular implants that have had associated infection and are considered for re\u2010implantation. \u00a9 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1543\u20131550, 2018.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jor.23764","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T15:02:45Z","timestamp":1507129365000},"page":"1543-1550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Flash autoclave settings may influence eradication but not presence of well\u2010established biofilms on orthopaedic implant material"],"prefix":"10.1002","volume":"36","author":[{"given":"Dustin L.","family":"Williams","sequence":"first","affiliation":[{"name":"Department of Orthopaedics University of Utah Salt Lake City Utah"},{"name":"George E. Wahlen Department of Veterans Affairs Salt Lake City Utah"},{"name":"Department of Pathology University of Utah Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas B.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics University of Utah Salt Lake City Utah"},{"name":"George E. Wahlen Department of Veterans Affairs Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard T.","family":"Epperson","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics University of Utah Salt Lake City Utah"},{"name":"George E. Wahlen Department of Veterans Affairs Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Rothberg","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics University of Utah Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,22]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"ScottRD.2007. The direct medical costs of healthcare\u2010associated infections in U.S. hospitals and the benefits of prevention. 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