{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:58:05Z","timestamp":1789505885029,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201206240123"],"award-info":[{"award-number":["201206240123"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Vitamin E stabilization successfully improved long\u2010term oxidation resistance of wear\u2010resistant ultra\u2010high\u2010molecular\u2010weight polyethylene (UHMWPE) used for joint implants. Stabilization can be achieved by blending an antioxidant into the UHMWPE resin powder before consolidation and irradiation. Balancing the wear resistance and vitamin E content in the blend is the current challenge with this approach, because vitamin E hinders crosslinking of UHMWPE during irradiation, which decreases wear resistance. The vitamin E concentration in the blend is generally limited to less than 0.3\u2009wt%. Wear\u2010 and oxidation\u2010resistant UHMWPE has been obtained previously by consolidating blends of pre\u2010irradiated UHMWPE powders (XPE) into an unmodified polyethylene matrix (PE), where the improvement in wear rate depended on the radiation dose and fraction of XPE. We hypothesized that increasing the vitamin E content in the unirradiated matrix would not compromise wear and would further improve the oxidative stability of XPE\/PE blends. Pin\u2010on\u2010disk wear testing showed that the XPE\/PE blends containing 0.1\u20131.0\u2009wt% vitamin E in the matrix had comparable wear rates. We used an aggressive accelerated aging test in the presence of the pro\u2010oxidant squalene and oxidation induction time (OIT) test and found that higher amounts of vitamin E resulted in stronger oxidation resistance for XPE\/PE blends. The mechanical strength and toughness of the blends were not affected by changing the vitamin E content in the matrix. Stabilizing UHMWPE with higher vitamin E content may extend the service life of UHMWPE implants. \u00a9 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1860\u20131867, 2018.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jor.23835","type":"journal-article","created":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T13:48:51Z","timestamp":1513086531000},"page":"1860-1867","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Increased oxidative protection by high active vitamin E content and partial radiation crosslinking of UHMWPE"],"prefix":"10.1002","volume":"36","author":[{"given":"Jia\u2010Zhuang","family":"Xu","sequence":"first","affiliation":[{"name":"Harris Orthopaedic Laboratory Massachusetts General Hospital 55 Fruit Street Boston Massachusetts 02114"},{"name":"Polymer Science and Engineering Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith K.","family":"Wannomae","sequence":"additional","affiliation":[{"name":"Harris Orthopaedic Laboratory Massachusetts General Hospital 55 Fruit Street Boston Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhun K.","family":"Muratoglu","sequence":"additional","affiliation":[{"name":"Harris Orthopaedic Laboratory Massachusetts General Hospital 55 Fruit Street Boston Massachusetts 02114"},{"name":"Department of Orthopaedic Surgery Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru","family":"Oral","sequence":"additional","affiliation":[{"name":"Harris Orthopaedic Laboratory Massachusetts General Hospital 55 Fruit Street Boston Massachusetts 02114"},{"name":"Department of Orthopaedic Surgery Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100170203"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(99)00039-3"},{"key":"e_1_2_8_4_1","first-page":"46","article-title":"The problem is osteolysis","volume":"311","author":"Harris W","year":"1995","journal-title":"Clin Orthop"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-011-1872-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(95)00349-5"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000246547.18187.0b"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00021-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/b13521"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-806X(01)00431-5"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma00225a009"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0141-3910(91)90125-B"},{"key":"e_1_2_8_13_1","first-page":"449","volume-title":"UHMWPE biomaterials handbook","author":"Kurtz S","year":"2015"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1054\/arth.2001.20540"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.01006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.01017"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.32507"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1717-6"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.12.048"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.08.025"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.04.026"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.05.004"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.02.035"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1019892004830"},{"key":"e_1_2_8_25_1","unstructured":"XuJ\u2010Z MuratogluOK OralE.2014. Wear resistant and tough UHMWPE by using irradiated powder blends. Annual Meeting of the Orthopaedic Research Society p. 1297."},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1054\/arth.2001.23718"},{"key":"e_1_2_8_27_1","volume-title":"On post\u2010irradiation oxidation of vitamin E\u2010stabilized UHMWPE","author":"Costa L"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-011-2150-1"},{"key":"e_1_2_8_29_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/jbm.b.32805","article-title":"In vivo oxidation in retrieved highly crosslinked tibial inserts","volume":"101","author":"Currier B","year":"2013","journal-title":"J Biomed Mater Res"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33240"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.01.076"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2011.03.024"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2005.07.009"},{"key":"e_1_2_8_34_1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/jbm.b.32807","article-title":"Increasing irradiation temperature maximizes vitamin E grafting and wear resistance of UHMWPE","volume":"101","author":"Oral E","year":"2013","journal-title":"J Biomed Mater Res"},{"key":"e_1_2_8_35_1","unstructured":"NeilsA OralE MuratogluO.The initial concentration of vitamin E in irradiated UHMWPE affects vitamin E grafting. Paper presented at: 59th Annual Meeting of the Orthopaedic Research Society2013; San Antonio TX."},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2010.04.018"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23168"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.23835","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.23835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T17:05:04Z","timestamp":1719680704000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.23835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,3]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1002\/jor.23835"],"URL":"https:\/\/doi.org\/10.1002\/jor.23835","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,3]]},"assertion":[{"value":"2017-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}