{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T05:38:37Z","timestamp":1774762717625,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T00:00:00Z","timestamp":1534204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Spinal fusion and bone defects after injuries, removal of bone tumors, and infections require repair by implantation. In this study, we show self\u2010assembling peptide (SPG\u2010178) hydrogel\u2010induced bone healing in vivo. Posterolateral lumbar fusion and tibial intramedullary models of rabbits were prepared. In the tibia model, micro\u2010CT analysis revealed a significantly higher degree of newly formed bone matrix in the SPG\u2010178 group compared to the other groups. SEM\/3D micrographs showed that the cavity filled with SPG\u2010178 had collagen fibers attached to host bone. After 28 days, samples from the SPG\u2010178 group showed significant repair of the defect. In the posterolateral lumbar fusion models, micro\u2010CT showed a tendency for a higher degree of newly formed bone matrix in the SPG\u2010178 group compared to the \u03b2\u2010TCP and bone chips only groups. Von Kossa staining showed marked new bone formation attached to the lamina that was most prominent at the implanted SPG\u2010178 composite margin. SPG\u2010178 is a material that is likely to be used in clinical applications because it has several benefits. These include its favorable bone conduction properties, its ability to act as a support for various cells and growth factors, its lack of infection risk compared with materials of animal origin such as ECM, and the ease with which it can be used to fill defects with complex shapes and be combined with a wide range of other materials. \u00a9 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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