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The objective of this study was to evaluate knee gait variables, muscle co\u2010contraction indices and knee joint loading in young subjects with anterior cruciate ligament deficiency (ACLD, <jats:italic>n<\/jats:italic>\u2009=\u200936), versus control subjects (<jats:italic>n<\/jats:italic>\u2009=\u200912). A validated, electromyography\u2010informed model was used to estimate joint loading. For the involved limb of ACLD subjects versus control, muscle co\u2010contraction indices were higher for the medial (<jats:italic>p<\/jats:italic>\u2009=\u20090.018, effect size\u2009=\u20090.93) and lateral (<jats:italic>p<\/jats:italic>\u2009=\u20090.028, effect size\u2009=\u20090.83) agonist\u2013antagonist muscle pairs. Despite higher muscle co\u2010contraction, medial compartment contact force was lower for the involved limb, compared to both the uninvolved limb (mean difference\u2009=\u20090.39 body weight, <jats:italic>p<\/jats:italic>\u2009=\u20090.009, effect size\u2009=\u20090.70) as well as the control limb (mean difference\u2009=\u20090.57 body weight, <jats:italic>p<\/jats:italic>\u2009=\u20090.007, effect size\u2009=\u20091.14). Similar observations were made for total contact force. For involved versus uninvolved limb, the ACLD group demonstrated lower vertical ground reaction force (mean difference\u2009=\u20090.08 body weight, <jats:italic>p<\/jats:italic>\u2009=\u20090.010, effect size\u2009=\u20090.70) and knee flexion moment (mean difference\u2009=\u20091.32% body weight * height, <jats:italic>p<\/jats:italic>\u2009=\u20090.003, effect size\u2009=\u20090.76), during weight acceptance. These results indicate that high muscle co\u2010contraction does not always result in high knee joint loading, which is thought to be associated with knee osteoarthritis. Long\u2010term follow\u2010up is required to evaluate how gait alterations progress in non\u2010osteoarthritic versus osteoarthritic subjects. \u00a9 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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