{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T21:00:10Z","timestamp":1785013210788,"version":"3.55.0"},"reference-count":61,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:00:00Z","timestamp":1553731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>The aim of the current study was to investigate the multi\u2010dimensional characteristics of lumbar endplate defects in humans in relation to disc degeneration and other MRI phenotypes as well as their role with pain and disability. A total of 108 subjects were recruited and underwent 3T MRI of the lumbar spine. Structural endplate defects were identified and their dimensions were measured in terms of maximum width and depth, and were then standardized to the actual width of the endplate and depth of the vertebral body, respectively. Both width and depth of all endplate defects in each subject were added separately and scores were assigned on the basis of size from 1 to 3. Combining both scores provided \u201ccumulative endplate defect scores.\u201d Disc degeneration scores, Modic changes, disc displacement, HIZ, and facet joint changes were assessed. Subject demographics, pain profile, and Oswestry Disability Index (ODI) were also obtained. Endplate defects were observed in 67.5% of the subjects and in 13.5% of the endplates. All dimensions of endplate defects showed significance with disc degenerative scores, Modic changes, and posterior disc displacement (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Maximum width (<jats:italic>p<\/jats:italic>\u2009=\u20090.009) and its standardized value (<jats:italic>p<\/jats:italic>\u2009=\u20090.02), and cumulative endplate defect scores (<jats:italic>p<\/jats:italic>\u2009=\u20090.004) increased with narrow facet joints. Cumulative endplate defect scores showed a strong positive association with ODI (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) compared to disc degenerative scores. Large size endplate defects were strongly associated with degenerative spine changes and more back\u2010related disability. Findings from this study stress the need to assess endplate findings from a multi\u2010dimensional perspective, whose role may have clinical utility. \u00a9 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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