{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:36:53Z","timestamp":1792190213768,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T00:00:00Z","timestamp":1546473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Infrapatellar fat pad has been implicated in knee osteoarthritis. We examined whether infrapatellar fat pad volume is associated with quantitative cartilage changes using magnetic resonance imaging T1\u03c1 mapping. Fifty\u2010eight knees of knee pain patients (19 men, 39 women, mean age 57.0 [range 29\u201385] years) who were conservatively managed and had &gt;1 T1\u03c1 mapping images taken over time were evaluated. We used three slices from the medial femoral and tibial cartilage; areas showing T1\u03c1 values &lt;130\u2009ms and &gt;50\u2009ms were designated as having cartilage degeneration. Cases were categorized into three groups: Improvement, No Change, and Deterioration. Fat\u2010suppressed T2\u2010weighted sagittal magnetic resonance images were used for measuring infrapatellar fat pad volume. Percent change in infrapatellar fat pad volume was \u22125.01\u2009\u00b1\u20095.66%, \u22122.06\u2009\u00b1\u20094.92%, and 0.05\u2009\u00b1\u20096.09% in the Improvement (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922), No Change (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922), and Deterioration (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914) groups, respectively, demonstrating significantly reduced infrapatellar fat pad volume in the Improvement group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Multivariate regression analyses revealed that the percent change in infrapatellar fat pad volume significantly affected T1\u03c1 change category independent of age, sex, follow\u2010up period, baseline infrapatellar fat pad volume, and Kellgren\u2010Lawrence grade. Infrapatellar fat pad volume and obesity or body weight change showed no correlation. Infrapatellar fat pad volume was reduced in patients with improved quantitative cartilage assessment on magnetic resonance imaging T1\u03c1 mapping. This is the first study demonstrating associations between quantitative cartilage changes and infrapatellar fat pad morphological changes, suggesting a detrimental role of infrapatellar fat pad volume in articular cartilage degeneration. \u00a9 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jor.24201","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T04:54:28Z","timestamp":1544504068000},"page":"593-600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Volume change in infrapatellar fat pad is associated not with obesity but with cartilage degeneration"],"prefix":"10.1002","volume":"37","author":[{"given":"Tadashi","family":"Masaki","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Nippon Medical School 1\u20101\u20105 Sendagi Bunkyo\u2010ku Tokyo 113\u20108603 Japan"},{"name":"Department of Orthopaedic Surgery University of Health and Welfare Hospital 537\u20103 Iguchi Nasu\u2010shiobara Tochigi 329\u20102763 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University of Health and Welfare Hospital 537\u20103 Iguchi Nasu\u2010shiobara Tochigi 329\u20102763 Japan"},{"name":"AIC Yaesu Clinic 2\u20101\u201018 Nihonbashi Chuo\u2010ku Tokyo 103\u20100027 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanshiro","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Minami\u2010Shinjuku Orthopaedic Rehabilitation Clinic 2\u201016\u20107 Yoyogi Shibuya\u2010ku Tokyo 151\u20100053 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Futoshi","family":"Ikuta","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Nippon Medical School 1\u20101\u20105 Sendagi Bunkyo\u2010ku Tokyo 113\u20108603 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