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Using New Zealand White rabbits (NZWr), we aimed to evaluate if ribose\u2010treated allografts can unite with host bone (compared to untreated (fresh\u2010frozen) and conventionally\u2010irradiated allografts). A critically\u2010sized defect was created in the radii of NZWr and reconstructed with allografts fixed with an intramedullary Kirschner wire. Healing and union were assessed at 2, 6, and 12 weeks post operation, with radiographs, \u00b5CT, static and dynamic histomorphometry, backscatter electron microscopy, and torsion testing. Intramedullary fixation achieved stable reconstructions and bony union in all groups and no differences were found in the radiographic and biomechanical parameters tested. Interestingly, \u03b3\u2010irradiated allografts had significantly less bone volume due to evident resorption of the grafts. In contrast, ribose pre\u2010treatment protected \u03b3\u2010irradiated allografts from this bone loss, with results similar to the fresh frozen controls. In conclusion, ribose\u2010pretreated \u03b3\u2010irradiated allografts were able to unite in vivo. In addition to achieving bony union with host bone, ribose pre\u2010treatment may protect against allograft resorption. \u00a9 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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