{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:03:23Z","timestamp":1790078603580,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T00:00:00Z","timestamp":1556150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Legg\u2013Calve\u2013Perthes disease is characterized by the capital femoral epiphyseal collapse, which occurs more reliably in the anterior quadrant than the more weight\u2010bearing lateral quadrant. The purpose of this study was to determine whether there is a vascular or microstructural predisposition for anterior femoral epiphyseal collapse in Perthes disease. Thirty\u2010two cadaveric proximal femoral epiphyses from 17 subjects (age 4\u201314 years old) underwent micro\u2010computed tomography at 10\u2010\u03bcm resolution. Each quadrant was analyzed for four markers of trabecular architecture: bone volume fraction (BV\/TV), trabecular thickness, trabecular separation (TbSp), and trabecular number (TbN). Vascular channels were then mapped in each quadrant, identified by correlating surface topography with cross\u2010sectional imaging. One\u2010way analysis of variance revealed an overall difference between quadrants (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) in BV\/TV, TbN, and TbSp. However, post hoc analysis revealed there was no significant difference between the anterior and lateral quadrants for any of the four markers of trabecular architecture. Vascular channel mapping illustrated a predominance of vessels in the posterior half of the epiphysis compared to the anterior half (8.7\u2009\u00b1\u20094.0 vs. 3.4\u2009\u00b1\u20093.1 vascular channels, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The lack of microstructural differences between the anterior and lateral quadrants, and the predominance of vascular channels in the posterior half of the epiphysis with posteriorly\u2010based medial femoral circumflex and ligamentum teres vessels suggests that the anterior femoral epiphysis may be a relative vascular watershed region, which predisposes it to collapse after the vascular insult of Perthes disease. Clinical significance: Improved understanding of the pathophysiology of anterior femoral epiphyseal collapse may inform future treatments aimed at revascularization. \u00a9 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Chen","sequence":"additional","affiliation":[{"name":"Texas A&amp;M Health Science Center, School of Medicine Temple Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry KW","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Excellence in Hip Disorders Texas Scottish Rite Hospital for Children Dallas Texas"},{"name":"Department of Orthopaedics, Southwestern Medical Center University of Texas Dallas 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