{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:09:14Z","timestamp":1790215754110,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Autologous vein wrapping is used to treat recurrent chronic constriction neuropathy and traumatic peripheral nerve injury. However, its use is restricted due to the inability to obtain sufficiently long veins for larger grafts. We previously reported that vein\u2010derived basic fibroblast growth factor (bFGF) promotes heme oxygenase\u20101 (HO\u20101), which reduces allodynia via its anti\u2010inflammatory properties. To mimic vein wrapping, we developed a collagen sheet impregnated with bFGF. Chronic constriction injury (CCI) was induced in male Wistar rats as a model of sciatic nerve injury, and the rats were divided into three groups: (i) untreated after CCI surgery (control group), (ii) treated with a collagen sheet wrap impregnated with phosphate\u2010buffered saline (PBS\/CS group), and (iii) treated with a collagen sheet wrap impregnated with bFGF (bFGF\/CS group). Pain behavior (von Frey test) was evaluated on postoperative days (PODs) 1, 5, 7, and 14. Quantitative polymerase chain reaction was conducted on sciatic nerve RNA to quantify HO\u20101 gene, <jats:italic>Hmox1<\/jats:italic>, expression. Enzyme\u2010linked immunosorbent assay were used to determine HO\u20101 protein levels on POD 1. von Frey testing showed significantly greater pain hypersensitivity in the control and PBS\/CS groups than the bFGF\/CS group. In the bFGF\/CS group, <jats:italic>Hmox1<\/jats:italic> messenger RNA and HO\u20101 protein levels were significantly increased in the sciatic nerve compared with the control and PBS\/CS groups on PODs 1 and 5 and POD 1, respectively. The bFGF\/CS group showed decreased allodynia and HO\u20101 induction, as observed with vein wrapping. Therefore, local application of bFGF may be an alternative treatment strategy for compressive neuropathy and peripheral nerve trauma in clinical settings. \u00a9 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2258\u20132263, 2019<\/jats:p>","DOI":"10.1002\/jor.24349","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T09:44:47Z","timestamp":1558518287000},"page":"2258-2263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Wrapping With Basic Fibroblast Growth Factor\u2010Impregnated Collagen Sheet Reduces Rat Sciatic Nerve Allodynia"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4673-4734","authenticated-orcid":false,"given":"Michiaki","family":"Mukai","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Graduate School of Medicine Chiba University  1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108677 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5148-914X","authenticated-orcid":false,"given":"Kentaro","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Kitasato University School of Medicine  Sagamihara City 1\u201015\u20101 Minami\u2010Ku Kitasato Sagamihara City Kanagawa 252\u20100374 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5394-7079","authenticated-orcid":false,"given":"Naoya","family":"Hirosawa","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Graduate School of Medicine Chiba University  1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108677 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery St. Marianna University School of Medicine  2\u201016\u20101 Sugao Miyamae\u2010ku Kanagawa 216\u20108511 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Kuniyoshi","sequence":"additional","affiliation":[{"name":"Department of Surgery Nagareyama Central Hospital  2\u2010132\u20102 Higashihatsuishi Nagareyama Chiba 270\u20100114 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Kitasato University School of Medicine  Sagamihara City 1\u201015\u20101 Minami\u2010Ku Kitasato Sagamihara City Kanagawa 252\u20100374 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Miyagi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Kitasato University School of Medicine  Sagamihara City 1\u201015\u20101 Minami\u2010Ku Kitasato Sagamihara City Kanagawa 252\u20100374 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Shonan University of Medical Sciences Research Institute  Nishikubo 500 Chigasaki City Kanagawa 253\u20100083 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Shiga","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Graduate School of Medicine Chiba University  1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108677 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Inage","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Graduate School of Medicine Chiba University  1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108677 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumihisa","family":"Orita","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Graduate School of Medicine Chiba University  1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108677 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takane","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Graduate School of Medicine Chiba University  1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108677 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Graduate School of Medicine Chiba University  1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108677 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Takaso","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Kitasato University School of Medicine  Sagamihara City 1\u201015\u20101 Minami\u2010Ku Kitasato Sagamihara City Kanagawa 252\u20100374 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Ohtori","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Graduate School of Medicine Chiba University  1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108677 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,20]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110079801901111"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110070002100608"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2009.12.019"},{"key":"e_1_2_7_1_5_1","first-page":"817","article-title":"Venous wrapping of nerves to prevent scarring","volume":"15","author":"Masear V","year":"1990","journal-title":"J Hand Surg"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e3182623970"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.22207"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200108000-00022"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.1920161110"},{"key":"e_1_2_7_1_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-7333"},{"key":"e_1_2_7_1_11_1","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20150204-04"},{"key":"e_1_2_7_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e3182956475"},{"key":"e_1_2_7_1_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhsu.2003.50029"},{"key":"e_1_2_7_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23674"},{"key":"e_1_2_7_1_15_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.01790"},{"key":"e_1_2_7_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23875"},{"key":"e_1_2_7_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35866"},{"key":"e_1_2_7_1_18_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015410023132"},{"key":"e_1_2_7_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.10008"},{"key":"e_1_2_7_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90209-6"},{"key":"e_1_2_7_1_21_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.20.040180.002301"},{"key":"e_1_2_7_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)90144-9"},{"key":"e_1_2_7_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(02)00119-X"},{"key":"e_1_2_7_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34841"},{"key":"e_1_2_7_1_25_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.37.1.517"},{"key":"e_1_2_7_1_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/3947"},{"key":"e_1_2_7_1_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.20.10925"},{"key":"e_1_2_7_1_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318286d085"},{"key":"e_1_2_7_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2010.07.014"},{"key":"e_1_2_7_1_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146427"},{"key":"e_1_2_7_1_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00307.x"},{"key":"e_1_2_7_1_32_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b16-00332"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.24349","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.24349","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jor.24349","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.24349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T19:36:11Z","timestamp":1694201771000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.24349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,20]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1002\/jor.24349"],"URL":"https:\/\/doi.org\/10.1002\/jor.24349","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,20]]},"assertion":[{"value":"2019-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}