{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:45:48Z","timestamp":1791557148457,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T00:00:00Z","timestamp":1567036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Mobility outcomes and changes in bone mineral density (BMD) of the spine and femoral necks in response to unilateral osseointegrated implants was investigated over a 3\u2010year period. A total of 48 unilateral amputees who received an osseointegrated implant, comprising 33 trans\u2010femoral amputees (TFA) and 15 trans\u2010tibial amputees (TTA), underwent dual\u2010energy X\u2010ray absorptiometry (DXA) scans of the lumbar spine (L2\u2013L4) and femoral necks at baseline, 1\u2010, and 3\u2010years follow\u2010ups. Mobility outcomes, including the Six\u2010Minute\u2010Walk Test (6MWT) and Timed\u2010Up\u2010and\u2010Go (TUG), were measured before surgery, at 1 year, and more than 2 years following the osseointegration procedure. We observed a significant increase (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) in <jats:italic>Z<\/jats:italic>\u2010score values in the femoral neck of the amputated side in TFA patients without a femoral neck lag screw at the 1\u2010 and 3\u2010year follow\u2010ups, as well as in TFA patients with a lag screw present at 3\u2010year follow\u2010up. The BMD at 1\u2010year follow\u2010up was found to be positively correlated with pre\u2010surgery 6MWT values in patients who were mobile using a traditional socket prosthesis before receiving an osseointegrated implant. These results suggest that osseointegrated implants induce a physiological response in the femoral neck of recipients and appear to be evidence of restored biomechanical loading in the proximal femur.  \u00a9 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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