{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:28:44Z","timestamp":1790512124420,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T00:00:00Z","timestamp":1576713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Rotator cuff (RC) tears are a common cause of upper extremity disability. Any tear size can result in subsequent muscle atrophy and fatty infiltration (FI). Preoperative muscle degeneration can predict repair and postoperative functional outcomes. Muscle residential fibro\u2010adipogenic progenitors (FAPs) are found to be capable of differentiating into beige adipocytes that release factors to promote muscle growth. This study evaluated the regenerative potential of local cell transplantation of beige FAPs to mitigate muscle degeneration in a murine massive RC tear model. Beige FAPs were isolated from muscle in UCP\u20101 reporter mice by flow cytometry as UCP\u20101\n                    <jats:sup>+<\/jats:sup>\n                    \/Sca1\n                    <jats:sup>+<\/jats:sup>\n                    \/PDGFR\n                    <jats:sup>+<\/jats:sup>\n                    \/CD31\n                    <jats:sup>\u2212<\/jats:sup>\n                    \/CD45\n                    <jats:sup>\u2212<\/jats:sup>\n                    \/integrin \u03b17\n                    <jats:sup>\u2212<\/jats:sup>\n                    . C57\/BL6J mice undergoing supraspinatus tendon tear with suprascapular nerve transection (TT\u2009+\u2009DN) received either no additional treatment, phosphate\u2010buffered saline injection, or beige FAP injection 2 weeks after the initial injury. Forelimb gait analysis was used to assess shoulder function with DigiGait. Mice were sacrificed 6 weeks after cell transplantation. FI, fibrosis, fiber size, vascularity were analyzed and quantified via ImageJ. Our results showed that beige FAP transplantation significantly decreased fibrosis, FI, and atrophy, enhanced vascularization compared with saline injection and non\u2010treatment groups. Beige FAP transplantation also significantly improved shoulder function as measured by gait analysis. This study suggests that beige\u2010differentiated FAPs may serve as a treatment option for RC muscle atrophy and FI, thus improving shoulder function in patients with massive RC tendon tears. \u00a9 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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