{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:47:53Z","timestamp":1761709673763,"version":"3.37.3"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,12,25]],"date-time":"2019-12-25T00:00:00Z","timestamp":1577232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR066562"],"award-info":[{"award-number":["R01AR066562"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Biomarkers are of interest to identify patients at risk for peri\u2010implant osteolysis and aseptic loosening. We used a rat model of particle\u2010induced peri\u2010implant osteolysis to investigate if early changes in biomarkers were associated with subsequent implant fixation strength. Implants were placed in rat femora, which were then challenged with intra\u2010articular knee injections of either clean polyethylene, lipopolysaccharide\u2010doped polyethylene, or cobalt\u2010chromium alloy particles, with particle\u2010free vehicle serving as control (n\u2009\u2265\u20098 per group). Rats were weighed weekly, blood was collected at weeks 0, 3, 5, and 6, and locomotor behavior was assessed 4 days before study conclusion. Rats were euthanized 6 weeks post surgery. Week 6 serum was analyzed for five bone remodeling markers, while longitudinal serum was assessed for osteocalcin. Bone\u2010implant contact, peri\u2010implant trabecular architecture, and implant fixation strength were measured. Rats challenged with cobalt\u2010chromium particles had a significant reduction in implant fixation strength compared with the vehicle\u2010control group (<jats:italic>P<\/jats:italic>\u2009=\u2009.034). This group also had elevated serum osteocalcin (<jats:italic>P<\/jats:italic>\u2009=\u2009.005), depressed weight gain (<jats:italic>P<\/jats:italic>\u2009=\u2009.001) and less frequent rearing behavior (<jats:italic>P<\/jats:italic>\u2009=\u2009.029). Regardless of group, change in serum osteocalcin at week 3 (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2212.368;<jats:italic>P<\/jats:italic>\u2009=\u2009.046), change in weight at week 2 (<jats:italic>r<\/jats:italic>\u2009=\u2009.586;<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), as well as weight change at all other time intervals were associated with fixation strength. The finding that early alterations in serum osteocalcin and body weight were predictive of subsequent implant fixation strength supports continued investigation of biomarkers for early detection of peri\u2010implant osteolysis and implant loosening. Further, change in biomarker levels was found to be more indicative of implant fixation status than any single measurement.<\/jats:p>","DOI":"10.1002\/jor.24563","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T10:43:53Z","timestamp":1576061033000},"page":"1216-1227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Early changes in serum osteocalcin and body weight are predictive of implant fixation in a rat model of implant loosening"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2594-3841","authenticated-orcid":false,"given":"Brittany M.","family":"Wilson","sequence":"first","affiliation":[{"name":"Department of Cell &amp; Molecular Medicine Rush University Medical Center Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7801-4849","authenticated-orcid":false,"given":"Meghan 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