{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:53:00Z","timestamp":1762005180798,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,12,25]],"date-time":"2019-12-25T00:00:00Z","timestamp":1577232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Focused high\u2010energy extracorporeal shockwave therapy (fhESWT) is used to improve fracture healing in cases of nonunion. In addition, it has been shown to have direct antibacterial effects. We evaluated fhESWT as an adjunct to conventional treatment in a clinically relevant rabbit model of fracture\u2010related infection (FRI). A humeral osteotomy in 31 rabbits was fixed with a seven\u2010hole locking compression plate. FRI was established with a clinical <jats:italic>Staphylococcus aureus<\/jats:italic> isolate. After 2 weeks, a revision surgery was performed with debridement, irrigation, and implant retention. Rabbits then received: no further treatment (controls); shockwaves (4000 impulses with 23\u2009kV at days 2 and 6 after revision); systemic antibiotics (rifampin and nafcillin); or the combination of antibiotics and shockwaves. Treatments were applied over 1 week. Blood cultures were taken before and after shockwave sessions. After another week without treatment, rabbits were euthanized and quantitative bacteriology was performed on implants and tissues to determine infection burden. Indicator organs (brain, heart, liver, lungs, kidneys, and spleen) were cultured to assess possible bacteremia. All the rabbits were infected at revision surgery as determined by the bacteriological culture of debrided materials. fhESWT in combination with antibiotic treatment lowered the bacterial burden 100\u2010fold compared with antibiotic treatment alone in all samples (<jats:italic>P<\/jats:italic>\u2009=\u2009.38). This effect was most prevalent for the implant sample (<jats:italic>P<\/jats:italic>\u2009=\u2009.08). No significant effect was seen for fhESWT alone compared with untreated controls. No signs of bacteremia occurred in blood cultures and organs. fhESWT appears safe and could be a helpful adjunct to conventional treatment in certain difficult\u2010to\u2010treat FRIs.<\/jats:p>","DOI":"10.1002\/jor.24565","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T10:44:32Z","timestamp":1576061072000},"page":"1351-1358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Focused high\u2010energy extracorporeal shockwaves as supplemental treatment in a rabbit model of fracture\u2010related infection"],"prefix":"10.1002","volume":"38","author":[{"given":"Jan","family":"Puetzler","sequence":"first","affiliation":[{"name":"Department of Trauma Surgery University Hospital of Muenster Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Milstrey","sequence":"additional","affiliation":[{"name":"AO Research Institute Davos Davos 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