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Ceragenins (CSAs) are a relatively new class of small\u2010molecule antimicrobials that target a broad range of Gram\u2010positive and Gram\u2010negative bacteria as well as fungi, viruses, and parasites. This review sets the context of the need for new antimicrobial strategies by cataloging the common pathogens associated with orthopedic infection and highlighting the increasing challenges of managing antibiotic\u2010resistant bacterial strains. It then comparatively describes the antimicrobial properties of CSAs with a focus on the CSA\u201013 family. More recently developed members of this family such as CSA\u201090 and CSA\u2010131 may have a particular advantage in an orthopedic setting as they possess secondary pro\u2010osteogenic properties. In this context, we consider several new preclinical studies that demonstrate the utility of CSAs in orthopedic models. Emerging evidence suggests that CSAs are effective against antibiotic\u2010resistant<jats:italic>Staphylococcus aureus<\/jats:italic>strains and can prevent the formation of biofilms. There remains considerable scope for developing CSA\u2010based treatments, either as coatings for orthopedic implants or as local or systemic antibiotics to prevent bone infection.<\/jats:p>","DOI":"10.1002\/jor.24615","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T11:21:27Z","timestamp":1580296887000},"page":"1883-1894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The application of ceragenins to orthopedic surgery and medicine"],"prefix":"10.1002","volume":"38","author":[{"given":"Aiken","family":"Dao","sequence":"first","affiliation":[{"name":"Orthopaedic Research &amp; Biotechnology Unit The Children's Hospital at Westmead Sydney NSW Australia"},{"name":"The Discipline of Child and Adolescent Health, Faculty of Medicine University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca 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