{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:54:40Z","timestamp":1792598080861,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672166"],"award-info":[{"award-number":["81672166"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inflammation is a contributing factor in osteocyte apoptosis, which is strongly associated with the development of glucocorticoid\u2010associated osteonecrosis of the femoral head (GA\u2010ONFH). Curcumin is a naturally derived drug that regulates immunity and inhibits inflammation. This study aimed to examine the capacity of curcumin to prevent osteocyte apoptosis and GA\u2010ONFH, while elucidating possible mechanisms of action. C57\/BL6 female mice were divided into control, GA\u2010ONFH, and curcumin\u2010treated GA\u2010ONFH groups. We determined the effect of curcumin on the polarization of RAW264.7 and the apoptosis of MLO\u2010Y4 cells. We found that curcumin reduced the infiltration of M1\u2010type macrophages in the femoral heads and alleviated systemic inflammation in GA\u2010ONFH models. Additionally, curcumin decreased the apoptosis of osteocytes in the femoral heads and the ratio of GA\u2010ONFH in mice. Further, in vitro curcumin intervention inhibited M1\u2010type polarization via the Janus kinase1\/2\u2010signal transducer and activator of transcription protein1 (JAK1\/2\u2010STAT1) pathway. Taken together, this study demonstrates that curcumin is effective in preventing osteocyte apoptosis and the development of GA\u2010ONFH in a mouse model. Curcumin prevents inflammatory\u2010mediated apoptosis of osteocytes in part through inhibition of M1 polarization through the JAK1\/2\u2010STAT1 pathway. These findings provide novel insights as well as a potential preventive agent for GA\u2010ONFH. This article is protected by copyright. All rights reserved.<\/jats:p>","DOI":"10.1002\/jor.24619","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T08:53:33Z","timestamp":1580720013000},"page":"2020-2030","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Curcumin prevents osteocyte apoptosis by inhibiting M1\u2010type macrophage polarization in mice model of glucocorticoid\u2010associated osteonecrosis of the femoral head"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8803-4974","authenticated-orcid":false,"given":"Shengyang","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunqing","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, 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