{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T16:02:52Z","timestamp":1768924972475,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Increasing numbers of arthroplasties are also accompanied by postoperative infections. The main purpose was to evaluate preoperative serum bilirubin levels between patients with and without infections after shoulder and knee arthroplasties. For this retrospective case\u2010control single\u2010center study, a total of 108 patients were extracted from a prospectively collected database. Eighteen patients with infections after shoulder (n\u2009=\u20098) and knee (n\u2009=\u200910) arthroplasty were matched by age, gender, and implant type in a 1:5\u2010scenario to 90 patients (40 shoulders and 50 knees) without postoperative infection. Demographic data, preoperative blood parameters, and postoperative infection\u2010related outcomes were evaluated. Total bilirubin was the only preoperative parameter significantly different between the infection (8.21\u2009\u00b1\u20093.25\u2009\u03bcmol\/L or 0.48\u2009\u00b1\u20090.19\u2009mg\/dL) and noninfection (10.78\u2009\u00b1\u20094.62\u2009\u03bcmol\/L or 0.63\u2009\u00b1\u20090.27\u2009mg\/dL; <jats:italic>P<\/jats:italic>\u2009=\u2009.014) group, while C\u2010reactive protein and other liver parameters were similar between the groups. Significantly more controls (92.1%) had preoperative bilirubin levels above 8.72\u2009\u03bcmol\/L or 0.51\u2009mg\/dL than cases (7.9%; <jats:italic>P<\/jats:italic>\u2009=\u2009.007). The 5\u2010year infection survival\u2010rate was 65.6% for patients with preoperative bilirubin levels\u2009&lt;\u20098.72\u2009\u03bcmol\/L or\u2009&lt;\u20090.51\u2009mg\/dL and 91.2% with\u2009\u2265\u20098.72\u2009\u03bcmol\/L or\u2009\u2265\u20090.51\u2009mg\/dL. Mildly decreased preoperative bilirubin levels with a cutoff at 8.72\u2009\u03bcmol\/L or 0.51\u2009mg\/dL were significantly associated to patients with infections after shoulder and knee arthroplasty. There were no differences in other blood parameters or comorbidities between patients with infections and their matched\u2010controls.<\/jats:p>","DOI":"10.1002\/jor.24620","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T11:21:00Z","timestamp":1580815260000},"page":"2074-2082","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mildly decreased preoperative bilirubin levels are associated with infections after shoulder and knee arthroplasty"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1198-4132","authenticated-orcid":false,"given":"Brenda","family":"Laky","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Vienna Shoulder and Sports Clinic Vienna Austria"},{"name":"Austrian Research Group for Regenerative and Orthopedic Medicine (AURROM), Division Orthopedic Research Vienna Austria"},{"name":"Department for Nutritional Sciences The University of Vienna Vienna Austria"},{"name":"MedSciCare Institute for Medical Research Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Alram","sequence":"additional","affiliation":[{"name":"Department for Nutritional Sciences The University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia K.","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Vienna Shoulder and Sports Clinic Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Pauzenberger","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Vienna Shoulder and Sports Clinic Vienna Austria"},{"name":"Department of Orthopedic Surgery Sports Surgery Clinic Dublin 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Austria"},{"name":"Austrian Research Group for Regenerative and Orthopedic Medicine (AURROM), Division Orthopedic Research Vienna Austria"},{"name":"HealthPi Medical Center, Orthopedic Unit Vienna 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