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Despite a relatively low incidence rate, periprosthetic joint infection is an increasing problem due to a substantial increase in arthroplasty surgeries over time. The current treatment is replacing the primary implant with a temporary bone cement spacer that releases antibiotics over time. However, the spacer is mechanically weak with an ineffective antibiotic release. Alternatively, three\u2010dimensional (3D)\u2010printed reservoirs in high\u2010strength devices have the potential to release antibiotics long term in a controlled manner. In this study, 3D\u2010printed reservoirs were loaded with calcium sulfate embedded with gentamicin. In vitro antibiotic release is tuned by varying reservoir parameters, such as channel length, diameter, and quantity. In addition, a straightforward computational model effectively predicts antibiotic release curves to rapidly design devices with a preferred release profile. Overall, this study highlights a novel approach to potentially develop high\u2010strength joint implants with the long\u2010term effective release of antibiotics to treat the periprosthetic joint infection.<\/jats:p>","DOI":"10.1002\/jor.24640","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T10:41:00Z","timestamp":1582713660000},"page":"2239-2249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Modulating antibiotic release from reservoirs in 3D\u2010printed orthopedic devices to treat periprosthetic joint infection"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1966-2464","authenticated-orcid":false,"given":"Brian","family":"Allen","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering and Materials Science, Edmund T. 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