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ACLT was surgically induced in the knees of skeletally mature New Zealand White rabbits (<jats:italic>n<\/jats:italic>\u2009=\u200914). ACL transected and contralateral knee compartments\u2014medial femur, lateral femur, medial tibia, and lateral tibia\u2014were harvested 2 (<jats:italic>n<\/jats:italic>\u2009=\u20098) and 8 weeks (<jats:italic>n<\/jats:italic>\u2009=\u20096) postsurgery. Twelve age\u2010matched nonoperated rabbits served as control. qMRI was conducted at 9.4\u2009T and included relaxation times T<jats:sub>1<\/jats:sub>, T<jats:sub>2<\/jats:sub>, continuous\u2010wave T<jats:sub>1\u03c1<\/jats:sub> (CWT<jats:sub>1\u03c1<\/jats:sub>), adiabatic T<jats:sub>1\u03c1<\/jats:sub> (AdT<jats:sub>1\u03c1<\/jats:sub>), adiabatic T<jats:sub>2\u03c1<\/jats:sub> (AdT<jats:sub>2\u03c1<\/jats:sub>), and relaxation along a fictitious field (T<jats:sub>RAFF<\/jats:sub>). For reference, quantitative histology and biomechanical measurements were carried out. Posttraumatic changes were primarily noted in the superficial half of the cartilage. Prolonged T<jats:sub>1<\/jats:sub>, T<jats:sub>2<\/jats:sub>, CWT<jats:sub>1\u03c1<\/jats:sub>, and AdT<jats:sub>1\u03c1<\/jats:sub> were observed in the lateral femur 2 and 8 weeks post\u2010ACLT, compared with the corresponding control and contralateral groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Collagen orientation was significantly altered in the lateral femur at 2 weeks post\u2010ACLT compared with the corresponding control group. In the medial femur, all the studied relaxation time parameters, except T<jats:sub>RAFF<\/jats:sub>, were increased 8 weeks post\u2010ACLT, as compared with the corresponding contralateral and control groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Similarly, significant proteoglycan loss was observed in the medial femur at 8 weeks following surgery (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Multiparametric MRI demonstrated early degenerative changes primarily in the superficial cartilage with T<jats:sub>1<\/jats:sub>, T<jats:sub>2<\/jats:sub>, CWT<jats:sub>1\u03c1<\/jats:sub>, and AdT<jats:sub>1\u03c1<\/jats:sub> sensitive to cartilage changes at 2 weeks after surgery.<\/jats:p>","DOI":"10.1002\/jor.24644","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T11:15:42Z","timestamp":1583320542000},"page":"1974-1986","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Multiparametric MR imaging reveals early cartilage degeneration at 2 and 8 weeks after ACL transection in a rabbit model"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7670-8134","authenticated-orcid":false,"given":"Abdul Wahed","family":"Kajabi","sequence":"first","affiliation":[{"name":"Research Unit of Medical Imaging, Physics and Technology University of Oulu Oulu 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