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Anterior cervical discectomy and fusion (ACDF) is a common treatment for radicular symptoms that do not resolve after conservative treatment. One mechanism by which ACDF is believed to resolve symptoms is by replacing degenerated disc tissue with bone graft to increase the neural foramen area, however in vivo evidence demonstrating this is lacking. The aim of this study was to evaluate the effects of age, pathology, and fusion on bony neural foramen area. Participants included 30 young adult controls (&lt;35 years old), 23 middle\u2010aged controls (36 to 60 years old), and 36 cervical arthrodesis patients tested before and after ACDF surgery. Participants\u2019 cervical spines were imaged in the neutral, full flexion, and full extension positions while seated within a biplane radiography system. A validated model\u2010based tracking technique determined three\u2010dimensional vertebral position and orientation and automated software identified the neural foramen area in each head position. The neural foramen area decreased throughout the entire sub\u2010axial cervical spine with age and pathology, however, no changes in neural foramen area were observed due solely to replacing degenerated disc tissue with bone graft. The neural foramen area was not associated with disc height in young adult controls, but moderate to strong associations were observed in middle\u2010aged controls. The results provide evidence to inform the debate regarding localized versus systemic spinal degeneration and provide novel insight into the mechanism of pain relief after ACDF.<\/jats:p>","DOI":"10.1002\/jor.24663","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T10:48:50Z","timestamp":1584096530000},"page":"671-679","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The effects of age, pathology, and fusion on cervical neural foramen area"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7552-1765","authenticated-orcid":false,"given":"Clarissa M.","family":"LeVasseur","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Pitcairn","sequence":"additional","affiliation":[{"name":"Department 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