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While different grafts and techniques have generally proven safe and effective, complications include shrinkage, extrusion, progression of joint pathology, and failure. The objective of this study was to assess the functional outcomes after MAT using three different clinically\u2010relevant methods in a preclinical canine model. The study was designed to test the hypothesis that fresh meniscal\u2010osteochondral allograft transplantation would be associated with significantly better function and joint health compared with\u00a0fresh\u2010viable or fresh\u2010frozen meniscus\u2010only allograft transplantations. Three months after meniscal release to induce meniscus\u2010deficient medial compartment disease, research hounds (n\u2009=\u200912) underwent MAT using meniscus allografts harvested from matched dogs. Three MAT conditions (n\u2009=\u20094 each) were compared: frozen meniscus\u2013fresh\u2010frozen meniscal allograft with menisco\u2010capsular suture repair; fresh meniscus\u2013fresh viable meniscal allograft (Missouri Osteochondral Preservation System (MOPS)\u2010preservation for 30 days) with menisco\u2010tibial ligament repair; fresh menisco\u2010tibial\u2013fresh, viable meniscal\u2010tibial\u2010osteochondral allografts (MOPS\u2010preservation for 30 days) with menisco\u2010tibial ligament preservation and autogenous bone marrow aspirate concentrate on OCA bone. Assessment was performed up to 6 months after MAT. Pain, comfortable range of motion, imaging, and arthroscopic scores as well histological and cell viability findings were superior (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.05) for the fresh menisco\u2010tibial group compared with the two other groups. Novel meniscal preservation and implantation techniques with fresh, MOPS\u2010preserved, viable meniscal\u2010osteochondral allografts with menisco\u2010tibial ligament preservation appears to be safe and effective for restoring knee function and joint health in this preclinical model. This has the potential to significantly improve outcomes after MAT.\n                  <\/jats:p>","DOI":"10.1002\/jor.24668","type":"journal-article","created":{"date-parts":[[2020,3,21]],"date-time":"2020-03-21T03:25:02Z","timestamp":1584761102000},"page":"154-164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Comparison of meniscal allograft transplantation techniques using a preclinical canine model"],"prefix":"10.1002","volume":"39","author":[{"given":"Anna J.","family":"Schreiner","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Thompson Laboratory for Regenerative Orthopaedics University of Missouri  Columbia Missouri"},{"name":"Department of Orthopaedic Surgery University of Missouri  Columbia Missouri"},{"name":"Department of Traumatology and Reconstructive Surgery, BG Center for Trauma and Reconstructive Surgery Eberhard\u2010Karls University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8467-6494","authenticated-orcid":false,"given":"James P.","family":"Stannard","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Thompson Laboratory for Regenerative Orthopaedics University of Missouri  Columbia Missouri"},{"name":"Department of Orthopaedic Surgery University of Missouri  Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristi R.","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Thompson Laboratory for Regenerative Orthopaedics University of Missouri  Columbia Missouri"},{"name":"Department of Orthopaedic Surgery University of Missouri  Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4755-867X","authenticated-orcid":false,"given":"Chantelle 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