{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:32:35Z","timestamp":1781278355881,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:00:00Z","timestamp":1586131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"American Academy of Cerebral Palsy and Developmental Medicine"},{"name":"University of Michigan Office of Health Equity and Inclusion Diversity Fund"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Individuals with cerebral palsy (CP) manifest skeletal fragility problems early in life and are vulnerable to nontrauma fracture (NTFx), which may exacerbate the risk of respiratory disease (RD)\u2013 the main cause of premature mortality for this population. The purpose of this study was to determine if adults with CP had a greater 12\u2010month risk of RD post\u2010NTFx compared to adults without CP. Data from 2011 to 2017 were leveraged from Optum Clinformatics Data Mart; a claims database from a single private payer in the United States diagnostic codes were used to identify adults (\u226518 years) with and without CP, NTFx, incident RD, and pre\u2010NTFx cardiometabolic diseases. Cox proportional hazards regression models were used to compare 12\u2010month RD incidence following NTFx with adjustment for sociodemographics and cardiometabolic diseases. Mean age (SD) at baseline was 57.5 (18.4) for adults with CP (n\u2009=\u2009646) and 61.8 (19.7) for adults without CP (n\u2009=\u2009321,482). During the follow\u2010up, 172 adults with CP (26.6%) and 73\u2009937 adults without CP (23.0%) developed RD. Adults with CP had higher 12\u2010month post\u2010NTFx RD incidence compared to adults without CP (hazard ratio [HR]\u2009=\u20091.20; 95% confidence interval [CI]\u2009=\u20091.03\u20101.37). When stratified by the RD subtype, adults with CP had a higher incidence of pneumonia (HR\u2009=\u20092.15; 95% CI\u2009=\u20091.56\u20102.95), interstitial\/pleura disease (HR\u2009=\u20092.13; 95% CI\u2009=\u20091.53\u20102.96), and other RD (eg, respiratory failure; HR\u2009=\u20092.33; 95% CI\u2009=\u20091.82\u20102.98), but not acute respiratory infection (HR\u2009=\u20090.93; 95% CI\u2009=\u20090.75\u20101.15) or chronic obstructive pulmonary disease (HR\u2009=\u20091.15; 95% CI\u2009=\u20090.86\u20101.53). Among privately insured adults with CP, NTFx is associated with greater risk of RD among adults with vs without CP.<\/jats:p>","DOI":"10.1002\/jor.24675","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T09:13:04Z","timestamp":1585645984000},"page":"2551-2558","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Nontrauma fracture increases risk for respiratory disease among adults with cerebral palsy"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2132-1527","authenticated-orcid":false,"given":"Daniel G.","family":"Whitney","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation University of Michigan  Ann Arbor Michigan"},{"name":"Institute for Healthcare Policy and Innovation University of Michigan  Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12268"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00471.2007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070288"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.10.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.10.046"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-014-2873-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000981"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0b013e3180317403"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S159405"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2018.07.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2269"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3694"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.05.007"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3089"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0b013e31828fc063"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002592"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S205839"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162206000211"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2013.11.002"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.14176"},{"key":"e_1_2_7_22_1","article-title":"Low\u2010trauma fracture increases 12\u2010month incidence of cardiovascular disease for adults with cerebral palsy","author":"Whitney DG","year":"2019","journal-title":"J Orthop Res"},{"key":"e_1_2_7_23_1","first-page":"e129","article-title":"Physician experiences providing primary care to people with disabilities","volume":"4","author":"McColl MA","year":"2008","journal-title":"Healthc Policy"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S205839"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.115060"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3733-1"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2017.17054"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2011.09.001"},{"key":"e_1_2_7_29_1","first-page":"721","article-title":"Validating the adapted Diabetes Complications Severity Index in claims data","volume":"18","author":"Chang HY","year":"2012","journal-title":"Am J Manag Care"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acap.2014.02.008"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207468"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-020857"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-005540"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32152-9"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmy027"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-011-9583-x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3216"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.12965\/jer.1632552.276"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2018.09.006"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-018-0183-1"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12950"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.02.024"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.03.066"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000864"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-2607"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.24675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.24675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jor.24675","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.24675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T19:31:14Z","timestamp":1693855874000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.24675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,6]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/jor.24675"],"URL":"https:\/\/doi.org\/10.1002\/jor.24675","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,6]]},"assertion":[{"value":"2019-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}