{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T17:08:07Z","timestamp":1783962487178,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR056019"],"award-info":[{"award-number":["AR056019"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Encapsulation of median nerves is a hallmark of overuse\u2010induced median mononeuropathy and contributes to functional declines. We tested if an antibody against CTGF\/CCN2 (termed FG\u20103019 or Pamrevlumab) reduces established neural fibrosis and sensorimotor declines in a clinically relevant rodent model of overuse in which median mononeuropathy develops. Young adult female rats performed a high repetition high force (HRHF) lever\u2010pulling task for 18 weeks. Rats were then euthanised at 18 weeks (HRHF untreated), or rested and systemically treated for 6 weeks with either an anti\u2010CCN2 monoclonal antibody (HRHF\u2010Rest\/FG\u20103019) or IgG (HRHF\u2010Rest\/IgG), with results compared with nontask control rats. Neuropathology was evident in HRHF\u2010untreated and HRHF\u2010Rest\/IgG rats as increased perineural collagen deposition and degraded myelin basic protein (dMBP) in median nerves, and increased substance P in lower cervical dorsal root ganglia (DRG), compared with controls. Both groups showed functional declines, specifically, decreased sensory conduction velocity in median nerves, noxious cold temperature hypersensitivity, and grip strength declines, compared with controls. There were also increases of ATF3\u2010immunopositive nuclei in ventral horn neurons in HRHF\u2010untreated rats, compared with controls (which showed none). FG\u20103019\u2010treated rats showed no increase above control levels of perineural collagen or dMBP in median nerves, Substance P in lower cervical DRGs, or ATF3\u2010immunopositive nuclei in ventral horns, and similar median nerve conduction velocities and thermal sensitivity, compared with controls. We hypothesize that neural fibrotic processes underpin the sensorimotor declines by compressing or impeding median nerves during movement, and that inhibiting fibrosis using an anti\u2010CCN2 treatment reverses these effects.<\/jats:p>","DOI":"10.1002\/jor.24709","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T13:10:40Z","timestamp":1588857040000},"page":"2396-2408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Blocking CTGF\/CCN2 reverses neural fibrosis and sensorimotor declines in a rat model of overuse\u2010induced median mononeuropathy"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5235-9803","authenticated-orcid":false,"given":"Mary F.","family":"Barbe","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology, Lewis Katz School of Medicine Temple University  Philadelphia 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