{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:46:01Z","timestamp":1778615161539,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T00:00:00Z","timestamp":1590105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["ASPIRE research grant (WI199899)"],"award-info":[{"award-number":["ASPIRE research grant (WI199899)"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","award":["Access to Insight Clinical Research Grant"],"award-info":[{"award-number":["Access to Insight Clinical Research Grant"]}],"id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ankle cartilage damage due to repeated joint bleeds often leads to altered gait in adult patients with hemophilia. It is therefore of clinical importance to develop an understanding of the biomechanical gait features in hemophilia patients with and without blood\u2010induced cartilage damage and age\u2010matched control subjects. We recruited a control group (n\u2009=\u200917), patients with hemophilia (PwH) without blood\u2010induced ankle cartilage damage (PwH_<jats:sub>NoCartDam<\/jats:sub>, n\u2009=\u20095) and PwH with severe blood\u2010induced ankle cartilage damage (PwH_<jats:sub>CartDam<\/jats:sub>, n\u2009=\u200919). We collected three\u2010dimensional gait analysis data with following outcome variables in the ankle, Chopart and the first metatarsophalangeal (MTP 1) joints: range of motion (ROM) during stance phase, peak joint moment and powers. Biomechanical loading (BW) was quantified as the joint reaction forces using inverse dynamic analysis. Loading rate (BW\/s) and impulse (BW*s) were calculated between 50% and 70% of stance phase. All biomechanical variables of the ankle joint were significantly lowered in the PwH_<jats:sub>CartDam<\/jats:sub> group compared with both the control subjects and the PwH_<jats:sub>NoCartDam<\/jats:sub> group. No compensatory biomechanical function was observed in other foot joints. An ankle loading rate of 2.64\u2009\u00b1\u20090.83 BW\/s was observed in the control group, which was significantly higher than 1.75\u2009\u00b1\u20090.43 BW\/s (<jats:italic>P<\/jats:italic>\u2009=\u2009.049) and 1.22\u2009\u00b1\u20090.59 BW\/s (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) in respectively the PwH_<jats:sub>NoCartDam<\/jats:sub> group and PwH_<jats:sub>CartDam<\/jats:sub> group. Patients with severe blood\u2010induced cartilage damage demonstrated a (mal)adaptive gait strategy as they experience difficulties to properly unload the ankle cartilage during walking.<\/jats:p>","DOI":"10.1002\/jor.24715","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T15:02:23Z","timestamp":1589382143000},"page":"2419-2428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Blood\u2010induced cartilage damage alters the ankle joint load during walking"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0809-4809","authenticated-orcid":false,"given":"Maarten","family":"Eerdekens","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Sciences, Musculoskeletal Rehabilitation Research Group KU Leuven  Heverlee Belgium"},{"name":"Department of Physical Medicine, Clinical Motion Analysis Laboratorium (CMAL) University Hospitals Leuven  Pellenberg Belgium"},{"name":"Department of Cardiovascular Sciences, Haemophilia Reference Center University Hospitals Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathelijne","family":"Peerlinck","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, Haemophilia Reference Center University Hospitals Leuven  Leuven Belgium"},{"name":"Department of Cardiovascular Sciences KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip","family":"Staes","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, Musculoskeletal Rehabilitation Research Group KU Leuven  Heverlee Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Baptiste","family":"Pialat","sequence":"additional","affiliation":[{"name":"Department of Radiology, Centre Hospitalier Lyon\u2010Sud Hospices Civils de Lyon  Pierre\u2010B\u00e9nite France"},{"name":"Department of Radiology Centre Hospitalier Lyon\u2010Sud  Pierre\u2010B\u00e9nite France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5429-8437","authenticated-orcid":false,"given":"Cedric","family":"Hermans","sequence":"additional","affiliation":[{"name":"Division of Haemostasis and Thrombosis (Haematology) Cliniques Universitaires Saint\u2010Luc, Universit\u00e9 catholique de Louvain  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-6850","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Lobet","sequence":"additional","affiliation":[{"name":"Division of Haemostasis and Thrombosis (Haematology) Cliniques Universitaires Saint\u2010Luc, Universit\u00e9 catholique de Louvain  Brussels Belgium"},{"name":"Division of Health Sciences, Neuromusculoskeletal Lab (NMSK) Universit\u00e9 Catholique de Louvain  Brussels Belgium"},{"name":"Department of Physical Medicine and Rehabilitation Cliniques Universitaires Saint\u2010Luc, Universit\u00e9 catholique de Louvain  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart","family":"Scheys","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration, Institute for Orthopaedic Research and Training (IORT) KU Leuven  Leuven Belgium"},{"name":"Department of Orthopaedics University Hospitals Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Deschamps","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine, Clinical Motion Analysis Laboratorium (CMAL) University Hospitals Leuven  Pellenberg Belgium"},{"name":"Department of Rehabilitation Sciences, Musculoskeletal Rehabilitations Research Group KU Leuven  Brugge 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