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One hundred seven subjects were studied, 57 of whom had aseptic failure (AF) and 50 PJI. The following synovial fluid biomarkers were tested using spectrophotometric assays, immunoassays, lateral flow tests, or test strips: leukocyte count, monocyte percentage, lymphocyte percentage, neutrophil percentage, C\u2010reactive protein (CRP), glucose, lactate, granulocyte\u2010macrophage colony\u2010stimulating factor, interferon\u2010\u03b3, interleukin\u20101\u03b2 (IL\u20101\u03b2), IL\u20102, IL\u20104, IL\u20105, IL\u20106, IL\u20108, IL\u201010, IL\u201012p70, IL\u201013, IL\u201017A, IL\u201023, tumor necrosis factor\u2010\u03b1, \u03b1\u2010defensin, and leukocyte esterase. The best\u2010performing synovial fluid biomarkers to differentiate PJI from AF\u2014that is, those with highest area under the curve compared to all other biomarkers\u2014were leukocyte count, percent neutrophils and percent monocytes, CRP, and \u03b1\u2010defensin (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001).<\/jats:p>","DOI":"10.1002\/jor.24766","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T18:06:52Z","timestamp":1591121212000},"page":"2664-2674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Comparative analysis of 23 synovial fluid biomarkers for hip and knee periprosthetic joint infection detection"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6274-7375","authenticated-orcid":false,"given":"Katyayini","family":"Sharma","sequence":"first","affiliation":[{"name":"Division of Clinical Microbiology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Ivy","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darci R.","family":"Block","sequence":"additional","affiliation":[{"name":"Clinical Core Laboratory Services Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2398-1724","authenticated-orcid":false,"given":"Matthew P.","family":"Abdel","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlen D.","family":"Hanssen","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Beauchamp","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin I.","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Rosemark","sequence":"additional","affiliation":[{"name":"Clinical Core Laboratory Services Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerryl E.","family":"Greenwood\u2010Quaintance","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Mandrekar","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6344-4141","authenticated-orcid":false,"given":"Robin","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology Mayo Clinic Rochester Minnesota"},{"name":"Division of Infectious Diseases Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5413.106884"},{"issue":"12","key":"e_1_2_8_3_1","first-page":"614","article-title":"New definition for periprosthetic joint infection","volume":"40","author":"Parvizi J","year":"2011","journal-title":"Am J Orthop"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2018.02.078"},{"key":"e_1_2_8_5_1","unstructured":"American Academy of Orthopaedic Surgeons. 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