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Twenty\u2010five subjects were enrolled in the study and assigned a variable\u2010stiffness shoe, and 19 subjects completed the 6\u2010month follow\u2010up. At baseline and follow\u2010up subjects underwent gait analysis in control and variable\u2010stiffness shoes, completed Western Ontario and McMaster Universities (WOMAC) questionnaires, and serum COMP concentrations were measured immediately before, 3.5 and 5.5 hours after a 30\u2010minute walking activity. Relationships between changes in KAM (first peak and impulse) and changes in (a) COMP levels in response to the 30\u2010minute walking activity and (b) WOMAC scores from baseline to 6\u2010month follow\u2010up were assessed by Pearson correlation coefficients. Changes in first peak KAM were associated with changes in COMP levels 5.5 hours postactivity from baseline to follow\u2010up (<jats:italic>R<\/jats:italic>\u2009=\u2009.564, <jats:italic>P<\/jats:italic>\u2009=\u2009.045). Subjects with greater reductions in KAM had larger decreases in COMP (expressed as a percent of preactivity levels) at follow\u2010up. Subjects with greater reductions in KAM impulse had significantly greater improvements in WOMAC Pain (<jats:italic>R<\/jats:italic>\u2009=\u2009\u2212.56, <jats:italic>P<\/jats:italic>\u2009=\u2009.015) and Function (<jats:italic>R<\/jats:italic>\u2009=\u2009\u2212.52, <jats:italic>P<\/jats:italic>\u2009=\u2009.028) scores at follow\u2010up. The study results demonstrated the magnitude of reduction in the KAM wearing a variable\u2010stiffness shoe is associated with decreases in mechanically stimulated COMP levels and pain\/function. This work suggests that interactions between COMP and joint loading during walking should be further investigated in future studies of treatment outcomes in OA.<\/jats:p>","DOI":"10.1002\/jor.24770","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T17:24:31Z","timestamp":1591291471000},"page":"619-627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Changes in knee adduction moment wearing a variable\u2010stiffness shoe correlate with changes in pain and mechanically stimulated cartilage oligomeric matrix levels"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3616-6585","authenticated-orcid":false,"given":"Jennifer C.","family":"Erhart\u2010Hledik","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Stanford University  Stanford California"},{"name":"VA Palo Alto Health Care System  Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7549-6504","authenticated-orcid":false,"given":"Gordhan B.","family":"Mahtani","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Stanford University  Stanford California"},{"name":"VA Palo Alto Health Care System  Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6853-5461","authenticated-orcid":false,"given":"Jessica L.","family":"Asay","sequence":"additional","affiliation":[{"name":"VA Palo Alto Health Care System  Palo Alto California"},{"name":"Department of Mechanical Engineering Stanford University  Stanford CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Migliore","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Stanford University  Stanford California"},{"name":"VA Palo Alto Health Care System  Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"VA Palo Alto Health Care System  Palo Alto California"},{"name":"Department of Radiology Stanford University  Stanford CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Andriacchi","sequence":"additional","affiliation":[{"name":"VA Palo Alto Health Care System  Palo Alto California"},{"name":"Department of Mechanical Engineering Stanford University  Stanford CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance R.","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Stanford University  Stanford California"},{"name":"VA Palo Alto Health Care System  Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.13805"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22897"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200704000-00012"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000357756"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/13547500902777608"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.08.019"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2008.02.001"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.07.003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)42671-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20908"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2004.09.007"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.07.018"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.59"},{"key":"e_1_2_7_15_1","first-page":"7","article-title":"Osteoarthrosis of the knee. 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