{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:16:23Z","timestamp":1785881783200,"version":"3.56.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:00:00Z","timestamp":1592956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004012","name":"Jane ja Aatos Erkon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["285909"],"award-info":[{"award-number":["285909"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["293970"],"award-info":[{"award-number":["293970"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["319440"],"award-info":[{"award-number":["319440"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["297033"],"award-info":[{"award-number":["297033"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["grant agreement 309962"],"award-info":[{"award-number":["grant agreement 309962"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chondral lesions lead to degenerative changes in the surrounding cartilage tissue, increasing the risk of developing post\u2010traumatic osteoarthritis (PTOA). This study aimed to investigate the feasibility of quantitative magnetic resonance imaging (qMRI) for evaluation of articular cartilage in PTOA. Articular explants containing surgically induced and repaired chondral lesions were obtained from the stifle joints of seven Shetland ponies (14 samples). Three age\u2010matched nonoperated ponies served as controls (six samples). The samples were imaged at 9.4\u2009T. The measured qMRI parameters included T<jats:sub>1<\/jats:sub>, T<jats:sub>2<\/jats:sub>, continuous\u2010wave T<jats:sub>1\u03c1<\/jats:sub> (CWT<jats:sub>1\u03c1<\/jats:sub>), adiabatic T<jats:sub>1\u03c1<\/jats:sub> (AdT<jats:sub>1\u03c1<\/jats:sub>), and T<jats:sub>2\u03c1<\/jats:sub> (AdT<jats:sub>2\u03c1<\/jats:sub>) and relaxation along a fictitious field (T<jats:sub>RAFF<\/jats:sub>). For reference, cartilage equilibrium and dynamic moduli, proteoglycan content and collagen fiber orientation were determined. Mean values and profiles from full\u2010thickness cartilage regions of interest, at increasing distances from the lesions, were used to compare experimental against control and to correlate qMRI with the references. Significant alterations were detected by qMRI parameters, including prolonged T<jats:sub>1<\/jats:sub>, CWT<jats:sub>1\u03c1<\/jats:sub>, and AdT<jats:sub>1\u03c1<\/jats:sub> in the regions adjacent to the lesions. The changes were confirmed by the reference methods. CWT<jats:sub>1\u03c1<\/jats:sub> was more strongly associated with the reference measurements and prolonged in the affected regions at lower spin\u2010locking amplitudes. Moderate to strong correlations were found between all qMRI parameters and the reference parameters (<jats:italic>\u03c1<\/jats:italic>\u2009=\u2009\u22120.531 to \u22120.757). T<jats:sub>1<\/jats:sub>, low spin\u2010lock amplitude CWT<jats:sub>1\u03c1<\/jats:sub>, and AdT<jats:sub>1\u03c1<\/jats:sub> were most responsive to changes in visually intact cartilage adjacent to the lesions. In the context of PTOA, these findings highlight the potential of T<jats:sub>1<\/jats:sub>, CWT<jats:sub>1\u03c1<\/jats:sub>, and AdT<jats:sub>1\u03c1<\/jats:sub> in evaluation of compositional and structural changes in cartilage.<\/jats:p>","DOI":"10.1002\/jor.24780","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T14:23:35Z","timestamp":1592317415000},"page":"63-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Evaluation of articular cartilage with quantitative MRI in an equine model of post\u2010traumatic osteoarthritis"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7670-8134","authenticated-orcid":false,"given":"Abdul Wahed","family":"Kajabi","sequence":"first","affiliation":[{"name":"Research Unit of Medical Imaging, Physics and Technology University of Oulu  Oulu Finland"},{"name":"Medical Research Center Oulu University of Oulu and Oulu University Hospital  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0447-2796","authenticated-orcid":false,"given":"Victor","family":"Casula","sequence":"additional","affiliation":[{"name":"Research Unit of Medical Imaging, Physics and Technology University of Oulu  Oulu Finland"},{"name":"Medical Research Center Oulu University of Oulu and Oulu University Hospital  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaakko K.","family":"Sarin","sequence":"additional","affiliation":[{"name":"Department of Applied Physics University of Eastern Finland  Kuopio Finland"},{"name":"Diagnostic Imaging Center Kuopio University Hospital  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juuso H.","family":"Ketola","sequence":"additional","affiliation":[{"name":"Research Unit of Medical Imaging, Physics and Technology University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7329-3463","authenticated-orcid":false,"given":"Olli","family":"Nyk\u00e4nen","sequence":"additional","affiliation":[{"name":"Department of Applied Physics University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikae C. R.","family":"te Moller","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina A. D.","family":"Mancini","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jetze","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics University Medical Center Utrecht  the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold","family":"Brommer","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ren\u00e9 van Weeren","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos","family":"Malda","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine Utrecht University  Utrecht the Netherlands"},{"name":"Department of Orthopaedics University Medical Center Utrecht  the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"T\u00f6yr\u00e4s","sequence":"additional","affiliation":[{"name":"Department of Applied Physics University of Eastern Finland  Kuopio Finland"},{"name":"Diagnostic Imaging Center Kuopio University Hospital  Kuopio Finland"},{"name":"School of Information Technology and Electrical Engineering The University of Queensland  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miika T.","family":"Nieminen","sequence":"additional","affiliation":[{"name":"Research Unit of Medical Imaging, Physics and Technology University of Oulu  Oulu Finland"},{"name":"Medical Research Center Oulu University of Oulu and Oulu University Hospital  Oulu Finland"},{"name":"Department of Diagnostic Radiology Oulu University Hospital  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5678-0689","authenticated-orcid":false,"given":"Mikko J.","family":"Nissi","sequence":"additional","affiliation":[{"name":"Research Unit of Medical Imaging, Physics and Technology University of Oulu  Oulu Finland"},{"name":"Department of Applied Physics University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4085\/1062-6050-51.5.08"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000131638.81519.de"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21359"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2019.08.004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22316"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.12.009"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.04.023"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42543-w"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2008.09.005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910390612"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1218"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1208"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25401"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198511000-00002"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910380602"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/157341108783339115"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10053-2"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25616"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22372"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603511406531"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31670-5"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.06.009"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(72)90010-3"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2007.01.015"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-019-02280-7"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00501401"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.20551"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546505275487"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1991.tb02712.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-4533(01)00123-0"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199704000-00022"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24644"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23127"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22933"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2009.08.001"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2282012012"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10216"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.06.002"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.11.019"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2322030976"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20672"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20241"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2004.05.003"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2009.05.023"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.2001.2340"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22372"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2013.06.004"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25616"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2017.12.006"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/03008207.2018.1455670"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.24780","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.24780","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jor.24780","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.24780","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T14:27:21Z","timestamp":1692541641000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.24780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,24]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/jor.24780"],"URL":"https:\/\/doi.org\/10.1002\/jor.24780","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,24]]},"assertion":[{"value":"2020-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}