{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T15:30:51Z","timestamp":1781969451952,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01 AR071444"],"award-info":[{"award-number":["R01 AR071444"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R03 ARR067504"],"award-info":[{"award-number":["R03 ARR067504"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Post\u2010traumatic joint contracture (PTJC) in the elbow is a biological problem with functional consequences. Restoring elbow motion after injury is a complex challenge because contracture is a multi\u2010tissue pathology. We previously developed an animal model of elbow PTJC using Long\u2010Evans rats and showed that the capsule and ligaments\/cartilage were the primary soft tissues that caused persistent joint motion loss. The objective of this study was to evaluate tissue\u2010specific changes within the anterior capsule and lateral collateral ligament (LCL) that led to their contribution to elbow contracture. In our rat model of elbow PTJC, a unilateral surgery replicated damage that commonly occurs due to elbow dislocation. Following surgery, the injured limb was immobilized for 42 days. The capsule and LCL were evaluated after 42 days of immobilization or 42 days of immobilization followed by 42 days of free mobilization. We evaluated extracellular matrix protein biochemistry, non\u2010enzymatic collagen crosslink content, tissue volume with contrast\u2010enhanced micro\u2010computed tomography, and tissue mechanical properties. Increased collagen content, but not collagen density, was observed in both injured limb capsules and LCLs, which was consistent with the increased tissue volume. Injured limb LCLs exhibited decreased normalized maximum force, and both tissues had increased immature collagen cross\u2010links compared to control. Overall, increased tissue volume and immature collagen crosslinks in the capsule and LCL drive their contribution to elbow contracture in our rat model.<\/jats:p>","DOI":"10.1002\/jor.24781","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T16:14:02Z","timestamp":1592410442000},"page":"1800-1810","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Increased volume and collagen crosslinks drive soft tissue contribution to post\u2010traumatic elbow contracture in an animal model"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8827-5257","authenticated-orcid":false,"given":"Chelsey L.","family":"Dunham","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Washington University in St. Louis  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Steenbock","sequence":"additional","affiliation":[{"name":"Institute of Virology and Cell Biology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Brinckmann","sequence":"additional","affiliation":[{"name":"Institute of Virology and Cell Biology University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Department of Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex J.","family":"Reiter","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Washington University in St. Louis  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan M.","family":"Castile","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Washington University in St. Louis  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Chamberlain","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Washington University in St. Louis  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer P.","family":"Lake","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Washington University in St. Louis  St. Louis Missouri"},{"name":"Department of Mechanical Engineering Washington University in St. Louis  St. Louis Missouri"},{"name":"Department of Orthopaedic Surgery Washington University in St. Louis  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocl.2007.12.004"},{"key":"e_1_2_7_3_1","unstructured":"LuokkalaT TemperleyD BasuS et al.2018.Analysis of magnetic resonance imaging\u2013confirmed soft tissue injury pattern in simple elbow dislocations.JSES."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.J.00860"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.86B8.14962"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-013-2424-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocl.2007.12.001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2013.06.007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2012.11.010"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2007.09.015"},{"key":"e_1_2_7_11_1","first-page":"170","article-title":"Biomechanical study of ligaments around the elbow joint","author":"Regan WD","year":"1991","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196607000-00001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22981"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2016.09.059"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/CORR.0000000000000388"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.18.00246"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2004.09.032"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1058-2746(09)80053-0"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1058-2746(96)80004-8"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23007"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.227.13"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3233\/BIR-1980-171-212"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008207709152607"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2017.0018"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-9120(96)00003-6"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008208209160269"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)56248-7"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-413-1_6"},{"key":"e_1_2_7_29_1","first-page":"624","article-title":"The laboratory rat: relating its age with human's","volume":"4","author":"Sengupta P","year":"2013","journal-title":"Int J Prev Med"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100100202"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199704000-00031"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(83)90024-0"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.36354"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00409.2014"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.53.070184.003441"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/141.2.307"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/03008207.2018.1449837"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112391"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.2570010109"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.24781","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.24781","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jor.24781","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.24781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T22:00:55Z","timestamp":1693346455000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.24781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,26]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/jor.24781"],"URL":"https:\/\/doi.org\/10.1002\/jor.24781","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,26]]},"assertion":[{"value":"2020-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}