{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:19:38Z","timestamp":1790839178614,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR049069"],"award-info":[{"award-number":["R01 AR049069"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Scapholunate interosseous ligament tears are a common wrist injury in young and active patients that can lead to suboptimal outcomes after repair. This research aims to assess a multiphasic scaffold using 3D\u2010printing for reconstruction of the dorsal scapholunate interosseous ligament. The scaffold was surgically implanted in vivo in the position of the native rabbit medial collateral ligament. Two branches of treatment were implemented in the study. In the first group, the rabbits (n\u2009=\u20098) had the knee joint fixed in flexion for 4 weeks using 1.4\u2009mm K\u2010wires prior to sample harvesting. The second group (n\u2009=\u20098) had the rabbit knee joint immobilized for 4 weeks prior to K\u2010wire removal and mobilization for an additional 4 weeks prior to sample harvesting. Overall, samples were harvested at 4 weeks post\u2010surgery (immobilized group) and eight weeks post\u2010surgery (mobilized group). Mechanical tensile testing (n\u2009=\u20095\/group) and histology (n\u2009=\u20093\/group) of the constructs were conducted. Tissue integration and maturation were observed resulting in increased mechanical strength of the operated joint at 8 weeks (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Bone and ligament tissues were regenerated in their respective compartments with structural and mechanical properties approaching those reported for the human dorsal SLIL ligament. Clinical Significance: This proof of concept study has demonstrated that the synthetic multiphasic scaffold was capable of regenerating both bone and ligament while also withstanding the physiological load once implanted in the rabbit knee. The artificial scaffold may provide an alternative to current techniques for reconstruction of scapholunate instability or other ligament injuries in the hand and wrist.<\/jats:p>","DOI":"10.1002\/jor.24785","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T16:38:09Z","timestamp":1593016689000},"page":"1811-1824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Multiphasic scaffold for scapholunate interosseous ligament reconstruction: A study in the rabbit knee"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6034-4823","authenticated-orcid":false,"given":"Hayman","family":"Lui","sequence":"first","affiliation":[{"name":"School of Medicine Griffith University  Gold Coast Queensland Australia"},{"name":"Department of Orthopaedic Surgery Gold Coast University Hospital  Gold Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7937-4432","authenticated-orcid":false,"given":"Cedryck","family":"Vaquette","sequence":"additional","affiliation":[{"name":"School of Dentistry The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7640-2618","authenticated-orcid":false,"given":"Janet M.","family":"Denbeigh","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy","family":"Bindra","sequence":"additional","affiliation":[{"name":"School of Medicine Griffith University  Gold Coast Queensland Australia"},{"name":"Department of Orthopaedic Surgery Gold Coast University Hospital  Gold Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2886-1510","authenticated-orcid":false,"given":"Sanjeev","family":"Kakar","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4458-0946","authenticated-orcid":false,"given":"Andre J.","family":"van Wijnen","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(96)80096-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200512000-00018"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200102000-00006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhsu.1999.0953"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2012.07.035"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900133"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.04.035"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2018.06.071"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2019.01.022"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1071100717753160"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2017.06.014"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01463.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33828"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3727\/000000005783982486"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0095399703258682"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0218810415500343"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/biores.2016.0032"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2011.0231"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546518818792"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23642"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhsu.1999.0963"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhsu.2002.36514"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(05)80146-7"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(98)80168-8"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1384743"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(02)00250-4"},{"issue":"1","key":"e_1_2_8_28_1","first-page":"87","article-title":"Normal and healing ligament vascularity: a quantitative histological assessment in the adult rabbit medial collateral ligament","volume":"188","author":"Bray RC","year":"1996","journal-title":"J Anat"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-2-287-99353-4_3"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2015.03.032"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100100202"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/036354658301100602"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orthres.2003.12.009"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2012.05.016"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2015.04.007"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2018.06.022"},{"key":"e_1_2_8_37_1","first-page":"97","article-title":"Correlating rabbit movement with load on its medial collateral ligament","volume":"33","author":"Spelier EL","year":"1996","journal-title":"Am Soc Mech Eng Bioeng Div (Publication) BED"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.2792268"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(03)00051-2"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100100404"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2003.09.011"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/03008207.2016.1187141"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.24785","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.24785","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jor.24785","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.24785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T22:01:45Z","timestamp":1693346505000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.24785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,7]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/jor.24785"],"URL":"https:\/\/doi.org\/10.1002\/jor.24785","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,7]]},"assertion":[{"value":"2019-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}