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Women have higher risks of sustaining non\u2010contact injuries, and are more likely to present with aberrant movement patterns associated with the mechanism of injury (MOI). We hypothesized that sex and MOI would influence gait after ACLR. Seventy participants, grouped by sex and MOI, completed biomechanical testing during over\u2010ground walking when they had full knee range of motion, trace or less knee effusion, greater than 80% quadriceps strength limb symmetry index, ability to hop on each leg without pain, and initiated running. Bilateral knee kinetics, kinematics, and joint contact forces were compared using mixed\u2010model analysis of variance (<jats:italic>\u03b1<\/jats:italic>\u2009=\u2009.05). There was a three\u2010way interaction effect of sex\u2009\u00d7\u2009MOI\u2009\u00d7\u2009limb for peak medial compartment contact force (<jats:italic>P<\/jats:italic>\u2009=\u2009.002), our primary outcome measure previously associated with OA development. Men with non\u2010contact injuries walked with asymmetry characterized by underloading of the involved limb. Men with contact injuries walked with the most symmetrical loading. In women, no clear pattern emerged based on MOI. Targeting, and possibly prioritizing interventions for athletes who present with gait asymmetries after ACLR based on sex and MOI, may be necessary to optimize outcomes. Statement of Clinical Significance: Sex and MOI may influence walking mechanics, and could be considered in future interventions to target gait symmetry, as a response to interventions may vary based on differences in sex and MOI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jor.24822","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:23:13Z","timestamp":1596759793000},"page":"1123-1132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Sex and mechanism of injury influence knee joint loading symmetry during gait 6 months after ACLR"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4166-5319","authenticated-orcid":false,"given":"Naoaki","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Physical Therapy University of Delaware Newark Delaware"},{"name":"Biomechanics and Movement Science Program University of Delaware Newark 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